http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-036585-A1
Outgoing Links
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| filingDate | 2000-02-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6aa678214f7481ad9936bb0619d67ba7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_77ad2dbdd08d3ca2c3bdd52febe8e779 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fd43668396368b576d44b802655c3a75 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_10cd522fd8d8efa074dc440bf8e290b0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_91a765ef57c327fcc48cbd88580103b1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_78e19d24a9d9d8e9329c9172484bfab2 |
| publicationDate | 2004-09-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-036585-A1 |
| titleOfInvention | COMPOUND DERIVED FROM SULFAM HYDROXAMIC ACID, INTERMEDIATE COMPOUNDS AND THE USE OF COMPOUNDS DERIVED FROM SULFAM HYDROXAMIC ACID IN THE MANUFACTURE OF MEDICINES TO TREAT AFFECTIONS RELATED TO THE PATOLOGICAL ACTIVITY OF METALOPROTEASP MMR |
| abstract | Compound derived from sulfamhydroxamic acid corresponding in structure to formula (1), or a salt thereof acceptable for pharmaceutical use, where: R1 and R2 are preferably taken together with the carbon to which they are attached to form a cycloalkyl group or more preferably a heterocycle group any of which is optionally substituted by one, two or three Rx substituents; or R1 and R2 are independently selected from the group consisting of: hydride, an alkyl group, optionally substituted with one, two or three groups independently selected from Rx substituents, an alkyloxyalkyl group, optionally substituted with one, two or three groups independently selected from substituents Rx, an alkylthioalkyl group, optionally substituted with one, two or three groups independently selected from Rx substituents, an alkenyl group, optionally substituted with one, two or three groups independently selected from Rx substituents, an alkynyl group, optionally substituted with one, two or three groups independently selected from Rx substituents, an aryl group, optionally substituted with one, two or three groups independently selected from Rx substituents, an arylalkyl group, optionally substituted with one, two or three groups independently selected from Rx substituents, a arylalkyloxyalkyl group, optionally substituted with one, two or three groups independently selected from Rx substituents, an aryloxyalkyl group, optionally substituted with one, two or three groups independently selected from Rx substituents, an arylthioalkyl group, optionally substituted with one, two or three groups independently selected from Rx substituents, an arylalkylthioalkyl group, optionally substituted with one, two or three groups independently selected from Rx substituents, a cycloalkyl or bicycloalkyl group, optionally substituted with one, two or three groups independently selected from Rx substituents, a cycloalkenyl group, optionally substituted with one, two or three groups independently selected from Rx substituents, a cycloalkylalkyl or bicycloalkylalkyl group, optionally substituted with one, two or three groups independently selected from Rx substituents, a cycloalkyloxyalkyl or bicycloalkyloxyalkyl group, optionally substituted with one, two or three groups independently selected from Rx substituents, a cycloalkylalkylxyalkyl or bicycloalkyloxyalkyl group, optionally substituted with one, two or three groups independently selected from Rx substituents, an optionally substituted cycloalkyl or bicycloalkyl group one, two or three groups independently selected from Rx; cycloalkylalkyl alkyl or bicycloalkylalkylthioalkyl, optionally substituted with one, two or three groups independently selected from Rx substituents, a heterocycle group, optionally substituted with one, two or three groups independently selected from Rx substituents, a heterocycloalkyl group, optionally substituted with one, two or three groups independently selected from Rx substituents, a heteroaryl group, optionally substituted with one, two or three groups independently selected from Rx substituents, a biarylalkyl group, optionally substituted with one, two or three groups independently selected from Rx substituents, an alkyl alkenyl group, optionally substituted with one, two or three groups independently selected from Rx substituents, an arylalkyl group, optionally substituted with one, two or three groups independently selected from Rx substituents, a heterocycloalkyl group ilium, optionally substituted with one, two or three groups independently selected from Rx substituents, a heterocycloalkyloxyalkyl group, optionally substituted with one, two or three groups independently selected from Rx substituents, a heteroarylalkenyl group, optionally substituted with one, two or three groups selected independently between Rx substituents, and a heteroarylalkyloxyalkyl group, optionally substituted with one, two or three groups independently selected from Rx substituents; where an Rx substituent is selected from the group consisting of a hydride, aryl, heteroaryl, heterocycle, aroyl, alkanoyl, heteroaroyl, halogen (F, Cl, Br, I), cyano, aldehyde (CHO, formyl), hydroxy, RcRd-amino (-NRcRd), RcRd-aminoalkyl, nitro, nitroso, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, alkoxy, aryloxy, heteroaryloxy, alkenyloxy, alkynyloxy, alkoxyaryl, alkoxyheteroaryl, alkoxyalkyl, Rc-oxyalkyl, alkoxyalkyl, alkylenedioxy, aryloxyalkyl, perfluoroalkyl , trifluoroalkyl, alkylthio, arylthio, alkyloxycarbonyl, alkyloxycarbonyloxy, aryloxycarbonyl, arylalkyloxycarbonyl, alkyloxycarbonyl-RC-amino, arilalquiloxicarbonil-Rc-amino, aryloxycarbonyloxy, carboxy, RcRd-aminocarbonyloxy, RcRd-aminocarbonyl, RcRd-aminoalkanoyl, hydroxy-Rc-aminocarbonyl, RcRd -aminosulfonyl, arylsulfonyl- (Rc) amino, RcRd-aminoalkoxy, RcRd-aminocarbonyl- (Rc) amino, trifluoromethylsulfonyl- (Rc) amino, heteroarylsulfonyl- (Rc) amino, alkylsulfonyl, arylsulfonyl- (Rc ) amino, arylsulfonyl- (Rc) aminocarbonyl, alkylsulfonyl- (Rc) amino, arylcarbonyl- (Rc) aminosulfonyl, and an alkylsulfonyl- (Rc) aminocarbonyl substituent; where Rc and Rd are independently selected from the group formed by a hydride, alkanoyl, arylalkyl, aroyl, bisalcoxialquilo, alkyl, haloalkyl, perfluoroalkyl, trifluoromethylalkyl, perfluoroalkoxyalkyl, alkoxyalkyl, cycloalkyl, heterocycloalkyl, heterocycloalkylcarbonyl, aryl, heterocyclo, heteroaryl, cycloalkylalkyl, aryloxyalkyl, heteroaryloxyalkyl, heteroarylalkoxyalkyl, heteroarylthioalkyl, arylsulfonyl, alkylsulfonyl, heteroarylsulfonyl, carboxyalkyl, alkoxycarbonylalkyl, aminocarbonyl, alquiliminocarbonilo, ariliminocarbonilo, heterocicloiminocarbonilo, arylthioalkyl, alkylthioalkyl, ariltioalquenilo, alkylthioalkenyl, heteroarylalkyl, haloalkanoyl, hydroxyalkanoyl, tiolalcanoilo, alkenyl, alkynyl, alkoxyalkyl, alkoxycarbonyl, aryloxycarbonyl, aminoalkylcarbonyl, hydroxyalkyl, aminoalkyl, aminoalkylsulfonyl, aminosulfonyl where the amino nitrogen is (i) unsubstituted or (ii) independently substituted or with one or two Ry radicals, or the substituents in the amino group taken together with the amino nitrogen form a saturated or partially unsaturated heterocycle group optionally substituted with one, two or three groups independently selected from Rw substituents or an optionally substituted heteroaryl group with one, two or three groups independently selected from Rv substituents; where Ry is selected from the group consisting of an arylalkyl, aryl, heteroaryl, heterocycle, alkyl, alkynyl, alkenyl, alkoxyalkyl, substituted or unsubstituted aminoalkyl, alkyloxycarbonyl, arylalkyloxycarbonyl, carboxyalkyl, haloalkyl, alkanoyl, aroyl or substituted aminoalkanoyl, substituted a hydroxyalkyl group, where each of said groups is optionally substituted by one or two groups independently selected from Ru substituents such as the substituents of the substituted aminoalkyl and substituted aminoalkanoyl groups; where Rv is selected from the group consisting of a hydride, aryl, heteroaryl, heterocycle, aroyl, alkanoyl, heteroaroyl, halogen (F, Cl, Br, I), cyano, aldehyde (CHO, formyl), hydroxy, amino, alkyl, alkenyl , alkynyl, cycloalkyl, cycloalkenyl, alkoxy, aryloxy, heteroaryloxy, alkenyloxy, alkynyloxy, alkoxyaryl, alkoxyheteroaryl, RyRz-amino, alkoxyalkyl, alkylenedioxy, aryloxyalkyl, perfluoroalkyl, trifluoroalkyl, alkylthio, arylthio, alkyloxycarbonyl, alkyloxycarbonyloxy, aryloxycarbonyl, arylalkyloxycarbonyl, arylalkyloxycarbonylamino, aryloxycarbonyloxy , carboxy, RyRz-aminocarbonyloxy, RyRz-aminocarbonyl, RyRz-aminoalkanoyl, hydroxyaminocarbonyl, RyRz-aminosulfonyl, RyRz-aminocarbonyl- (Ry) amino, trifluoromethylsulfonyl- (Ry) amino, heteroarylsulfonyl- (Ry) amino, arylsulfonyl , arylsulfonyl- (Ry) aminocarbonyl, alkylsulfonyl- (Ry) amino, arylcarbonyl- (Ry) aminosulfonyl, and an alkylsulfonyl- (Ry) aminocarbonyl substituent; where Rw is selected from the group consisting of a hydride, aryl, heteroaryl, heterocycle, aroyl, alkanoyl, heteroaroyl, halogen (F, Cl, Br, I), cyano, aldehyde (CHO, formyl), hydroxy, amino, alkyl, alkenyl , alkynyl, cycloalkyl, cycloalkenyl, alkoxy, aryloxy, heteroaryloxy, alkenyloxy, alkynyloxy, alkoxyaryl, alkoxyheteroaryl, RyRz-amino, alkoxyalkyl, alkylenedioxy, aryloxyalkyl, perfluoroalkyl, trifluoroalkyl, alkylthio, arylthio, alkyloxycarbonyl, alkyloxycarbonyloxy, aryloxycarbonyl, arylalkyloxycarbonyl, arylalkyloxycarbonylamino, aryloxycarbonyloxy , carboxy, RyRz-aminocarbonyloxy, RyRz-aminocarbonyl, RyRz-aminoalkanoyl, hydroxyaminocarbonyl, RyRz-aminosulfonyl, RyRz-aminocarbonyl- (Ry) amino, trifluoromethylsulfonyl- (Ry) amino, heteroarylsulfonyl- (Ry) amino, arylsulfonyl , arylsulfonyl- (Ry) aminocarbonyl, alkylsulfonyl- (Ry) amino, arylcarbonyl- (Ry) aminosulfonyl, and an alkylsulfonyl- (Ry) aminocarbonyl substituent; Rz is selected from the group consisting of an arylalkyl, aryl, heteroaryl, heterocycle, alkyl, alkynyl, alkenyl, alkoxyalkyl, alkoxyalkylalkyl, substituted or unsubstituted aminoalkyl, alkyloxycarbonyl, arylalkyl oxycarbonyl, carboxyalkyl, haloalkyl, alkanoyl, substituted alkyloalkanoalkyl a hydroxyalkyl group, where each of said groups are optionally substituted by one or two Ru substituents; where Ru was selected |
| priorityDate | 1999-02-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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