http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-035775-A1
Outgoing Links
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|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_966a6c1f382ec9bcb5e3839dfd73e5b8 |
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| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-549 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P15-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P13-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K- http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-5377 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P13-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D- http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D491-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-517 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P- |
| filingDate | 2001-12-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7b18fdeb3309d1a83f6da69d54c130c9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_87649b6d4c887882707b41a359e4a4c7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_db528ded7154ba1b34f485ca628f3aff http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_989e94d762fd6ea076c33070f1ab9ad3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a393cb284f6a57a0385000ca3f54b8d6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d82c217223b70aa011753a96e4e4e20f |
| publicationDate | 2004-07-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-035775-A1 |
| titleOfInvention | COMPOUNDS DERIVED FROM QUINAZOLIN-4-ONA AND BENZO [1,2,4] TIADIAZINE-1,1-DIOXIDE, ITS USE, A PROCESS FOR THEIR OBTAINING AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
| abstract | Compounds derived from quinazolin-4-one and benzo [1,2,4] thiadiazine-1,1-dioxide which conform to the general formula (1) in which: X is carbon or nitrogen; Y is carbon, X-Y considered together are two adjacent atoms of ring A, said ring being a fused aromatic ring of 5 or 6 atoms in the ring, which eventually incorporates 1 or 2 heteroatoms in the ring, chosen from N, O and S; Z is -C (O) - or -S (O) 2-; R is low molecular weight alkyl; R1 is hydrogen, low molecular weight alkyl, aryl, arylalkyl or arylaminocarbonyl, in which the aryl group may be substituted by 1 or 2 substituents chosen from low molecular weight alkyl, halogen, cyano or low molecular weight alkoxy, heteroaryl or heteroarylalkyl, in which the heteroaryl group may be substituted by 1 or 2 substituents chosen from low molecular weight alkyl, halogen, cyano or low molecular weight alkoxy; R2, R3 and R4, regardless of their occurrence, are hydrogen, low molecular weight alkyl, cycloalkyl or cycloalkylalkyl, in which the cycloalkyl group may be substituted by one or more substituents chosen from hydroxy, cyano, low molecular weight alkyl , low molecular weight alkoxy, halogeno (lower alkoxy weight), alkylthio, halogen, halogenalkyl, hydroxyalkyl, nitro, alkoxycarbonyl, amino, alkylamino, alkylsulfonyl, arylsulfonyl, alkylaminosulfonyl, arylaminosulfonyl, alkylsulfonylamino, arylsulfonylamino, alkylaminocarbonyl, arylaminocarbonyl, alkylcarbonylamino , arylcarbonylamino, phenyl or phenyl substituted by 1 or 2 substituents chosen from low molecular weight alkyl, halogen, cyano and low molecular weight alkoxy, aryl or arylalkyl, in which the aryl group may be substituted by one or more substituents chosen from hydroxy, cyano, low molecular weight alkyl, low molecular weight alkoxy, halogen- (low molecular weight alkoxy), alkylthio, halogen, halogenoalkyl, hydroxyalkyl, nitro, alkoxycarbonyl, amino, alkylamino, alkylsulfonyl, arylsulfonyl, alkylaminosulfonyl, arylaminosulfonyl, alkylsulfonylamino, arylsulfonylamino, alkylaminocarbonyl, arylaminocarbonylaminocarbonyl atoms they may be substituted by a methylenedioxy or ethylenedioxy group; heterocyclyl or heterocyclylalkyl, in which the heterocyclyl group may be substituted by one or more substituents chosen from hydroxy, hydroxyalkyl, oxo, cyano, cyanoalkyl, low molecular weight alkyl, low molecular weight alkoxy, alkoxyalkyl, halogen- (low alkoxy molecular weight), alkylthio, halogen, halogenoalkyl, hydroxyalkyl, nitro, alkoxycarbonyl, amino, alkylamino, alkylsulfonyl, arylsulfonylamino, alkylaminocarbonyl, arylaminocarbonyl, alkylcarbonylamino and arylcarbonylamino, heteroaryl or heteroarylalkyl, in which one may be substituted by the heteroaryl group chosen from hydroxy, cyano, low molecular weight alkyl, low molecular weight alkoxy, halogen- (low molecular weight alkoxy), alkylthio, halogen, halogenoalkyl, hydroxyalkyl, nitro, alkoxycarbonyl, amino, alkylamino, alkylsulfonyl, arylsulfonyl, alkylaminosulfonyl, arylaminosulfonyl, alkylsulfonylamino, arylsulfonylamino, alq uylaminocarbonyl, arylaminocarbonyl, alkylcarbonylamino and arylcarbonylamino, hydroxy, hydroxyalkyl, alkoxy, alkoxyalkyl, halogen, halogenalkyl, cyano, cyanoalkyl, - (CH2) nNR'R '', -C (NH) -NR'R '', - NC (NR ') -R' ', -N = CR'-NR'R' ', -SO2NR'R' ', -NSO2R', -C (O) R ', -C (O) NR'R' 'or - NC (O) R '; and n is a number from 0 to 3; with the proviso that if A is a benzene ring, at least one of R2, R3 and R4 is not hydrogen; or R2 and R3, if adjacent, taken together with the carbon atoms to which they are attached, can also form an aromatic ring, saturated or unsaturated, of 5 to 7 links, eventually incorporating one or two ring heteroatoms, chosen between N, S and O, which may be substituted by one or two substituents chosen from low molecular weight alkyl, halogen, cyano, alkylthio and low molecular weight alkoxy; R 'and R' 'regardless of their occurrence are hydrogen, low molecular weight alkyl, alkyl under substituted molecular weight, hydroxyalkyl, alkoxyalkyl, cycloalkyl, in which case the cycloalkyl group may be substituted by one or more substituents chosen from hydroxy, cyano, low molecular weight alkyl, low molecular weight alkoxy, halogen- (low molecular weight alkoxy), alkylthio, halogen, halogenoalkyl, hydroxyalkyl, nitro, alkoxycarbonyl, amino, alkylamino, alkylsulfonyl, arylsulfonyl, alkylaminosulfonyl, arylaminosulfonyl, alkylsulfonylamino, arylsulfonylamino, alkylaminocarbonyl, arylaminocarbonyl, alkylcarbonylamino, arylcarbonylamino and phenyl; aryl or arylalkyl, in which the aryl group may be substituted by one or more substituents chosen from hydroxy, cyano, low molecular weight alkyl, low molecular weight alkoxy, halogen- (low molecular weight alkoxy), alkylthio, halogen, halogenalkyl, hydroxyalkyl, nitro, alkoxycarbonyl, amino, alkylamino, alkylsulfonyl, arylsulfonyl, alkylaminosulfonyl, arylaminosulfonyl, alkylsulfonylamino, arylsulfonylamino, alkylaminocarbonyl, arylaminocarbonyl, alkylcarbonylamino and arylcarbonylants or substituted methylamino or two-methyloxy groups or one or two-methyloxy-substituted alkyl groups; heteroaryl or heteroarylalkyl, in which the heteroaryl group may be substituted by one or more substituents chosen from hydroxy, cyano, low molecular weight alkyl, low molecular weight alkoxy, halogen- (low molecular weight alkoxy), alkylthio, halogen, halogenalkyl, hydroxyalkyl, nitro, alkoxycarbonyl, amino, alkylamino, alkylsulfonyl, arylsulfonyl, alkylaminosulfonyl, arylaminosulfonyl, alkylsulfonylamino, arylsulfonylamino, alkylaminocarbonyl, arylaminocarbonyl, alkylcarbonylamino and arylcarbonylalkyl or heterocyclyl groups which may be substituted for heterocyclyl or heterocyclyl, which may be substituted for heterocyclyl or heterocyclyl, which may be substituted for heterocyclyl or heterocyclyl, which may be substituted for heterocyclyl or heterocyclyl, which may be substituted for heterocyclyl, heterocyclyl or heterocyclic acid, which may be substituted for heterocyclyl or heterocyclyl, which may be substituted for heterocyclyl, heterocyclyl or heterocyclyl, which may be substituted for heterocyclyl or heterocyclyl, or heterocyclic acid. chosen from hydroxy, hydroxyalkyl, oxo, cyano, cyanoalkyl, low molecular weight alkyl, low molecular weight alkoxy, alkoxyalkyl, halogen- (molecular weight alkoxy), alkylthio, halogen, halogenalkyl, nitro, alkoxycarbonyl, amino, alkylamino, alkylsulfonyl , arylsulfonylamino, alkylaminocarbonyl, arylaminocarbonyl, alkylcarbonylamino and arylcarbonylamino; heteroaryl or heteroarylalkyl, in which the heteroaryl group may be substituted by one or more substituents chosen from hydroxy, cyano, low molecular weight alkyl, low molecular weight alkoxy, halogen- (low molecular weight alkoxy), alkylthio, halogen, halogenalkyl, hydroxyalkyl, nitro, alkoxycarbonyl, amino, alkylamino, alkylsulfonyl, arylsulfonyl, alkylaminosulfonyl, arylaminosulfonyl, alkylsulfonylamino, arylsulfonylamino, alkylaminocarbonyl, arylaminocarbonyl, alkylcarbonylamino and arylcarbonylamino; or R 'and R' 'together with the nitrogen to which they are attached can form a ring of 5 to 7 links, eventually incorporating an additional heteroatom in the ring, chosen from N, O and S, this ring being able to be substituted by 1 or 2 substituents chosen from low molecular weight alkyl, halogen, cyano, or low molecular weight alkoxy; either individual isomers, racemic or non-racemic mixtures of isomers or pharmaceutically acceptable salts or solvates thereof. Pharmaceutical compositions containing them, process for obtaining them and use of the compounds as therapeutic active ingredients. The compounds of formula (1) are preferably useful for the treatment and prevention of disorders and symptoms of the urinary tract, sexual dysfunction or pain. |
| priorityDate | 2001-01-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 75.