http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-035609-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_da54f7ebbd2d9d8a82f92aca4d1b4e48 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D257-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F1-02 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D257-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F5-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F1-02 |
| filingDate | 2001-12-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9ab773cbdc304fc38089e9ec42b33f5e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f992b18109eeaadb6fcec0f969a2998c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6bc3b93e6c264d3ee0293c620996ebf6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c5f2278a7554bdd2feac273051cce25e |
| publicationDate | 2004-06-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-035609-A1 |
| titleOfInvention | LITHIUM COMPLEXES OF N- (1-HYDROXIMETHYL-2,3-DIHYDROXYPROPIL) -1,4,7-TRISCARBOXIMETHYL-1,4,7,10-TETRAAZACICLODODECANO, ITS PREPARATION AND USE |
| abstract | N- (1-hydroxymethyl-2,3-dihydroxypropyl) -1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane lithium complexes, of general formula (1), in which the three are described X represents a total of lithium ions and m hydrogen atoms, where n and m mean, each, the numbers 0 to 3; preferably 0.8 to 2.2 with the sum of n and m = 3, and Y represents chloride and bromide. A process for preparing the compounds of general formula (1) is also described, in which N- (6-hydroxy-2,2-dimethyl-1,3-dioxepan-5-yl) -1,4 is reacted, 7,10-tetraazacyclododecane or its complex with lithium chloride or lithium bromide, with chloroacetic or bromoacetic acid and lithium hydroxide in polar solvents, at temperatures between 40 and 150 ° C and at a pH value between 8 and 14. The lithium complexes of formula (1) are used to obtain the gadolinium complex of N (1-hydroxymethyl-2,3-dihydroxypropyl) -1,4,7-triscarboxymethyl-1,4,7,10-tetracyclododecane free of salts, without using ion exchangers. This last process of obtaining turns out to be more compatible with the environment and more economical. |
| priorityDate | 2000-12-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 35.