http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-035497-A1
Outgoing Links
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|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a7f82940e47ba7a1188f8e2ffca55e0f |
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| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P5-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4709 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4725 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4545 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-497 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-496 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-495 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-498 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P11-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-445 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P11-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D498-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-73 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-506 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-5377 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-28 |
| filingDate | 2001-10-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2004-06-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-035497-A1 |
| titleOfInvention | NON-IMIDAZOL COMPOUNDS, PHARMACEUTICAL COMPOSITION THAT INCLUDES THEM AND THE USE OF THEM FOR THE PREPARATION OF MEDICINES |
| abstract | A compound having the formula (1) or a pharmaceutically acceptable salt or solvate thereof, in which: (1) R1 is selected from: aryl, heteroaryl, heterocycloalkyl, alkyl, cycloalkyl, or alkylaryl, wherein said R1 groups are optionally substituted with 1 to 4 substituents independently selected from: halogen, hydroxyl, lower alkoxy, -CF3, CF3O, -NR4R5, phenyl, -NO2, -CO2R4, -CON (R4) 2 where each R4 is the same or different, -S (O) mN (R20) 2 where each R20 is the same or different H or a alkyl group preferably C1-4 alkyl, more preferably C1-2 alkyl and more preferably methyl, -CN, or alkyl, or (2) R1 and X taken together they form a selected group of formula (2) or (3); (3) X is selected from: = C (O), = C (NOR3), = C (NNR4R5), formula (4) or (5), (4) M1 is carbon, (5) M2 is selected from C or N, (6) M3 and M4 are independently selected from C or N, (7) Y is selected from: -CH2-, = C (O), = C (NOR20) (where R20 is as defined above ), o = C (S), (8) Z is a C1-6 alkyl group, (9) R2 is a 5- or 6-membered heteroaryl ring, said 6-membered heteroaryl ring comprising 1 or 2 nitrogen atoms, being the remaining carbon atoms, and said 5-membered heteroaryl ring containing 1 or 2 heteroatoms selected from: nitrogen, oxygen or sulfur, the rest of the carbon ring atoms being; said 5 or 6-membered heteroaryl ring being optionally substituted with 1 to 3 substituents independently selected from: halogen, hydroxyl, lower alkyl, lower alkoxy, -CF3, CF3O-, -NR4R5, phenyl, -NO2, -CO2R4, -CON (R4) 2, where each R4 is the same or different, -CH2NR4R5, - (N) C (NR4R5) 2, -CN; (10) R3 is selected from hydrogen, C1-6 alkyl, aryl, heteroaryl, heterocycloalkyl, arylalkyl, - (CH2) eC (O) N (R4) 2 where each R4 is the same or different, - (CH2) eC (O ) OR4, - (CH2) eC (O) R30 where R30 is a heterocycloalkyl group, such as, for example, morpholinyl, piperidinyl, piperazinyl or pyrrolidinyl, which includes formula (6), -CF3, or -CH2CF3, wherein said aryl, heteroaryl, heterocycloalkyl and the aryl portion of said arylalkyl, are optionally substituted with 1 to 3 substituents selected from: halogen, -OH, -OCF3, -CF3, -CN, -N (R45) 2, -CO2R45, or -C ( O) N (R45) 2, where each R45 is independently selected from: H, alkyl, alkylaryl or alkylaryl wherein said aryl moiety is substituted with 1 to 3 substituents independently selected from -CF3, -OH, halogen, alkyl, -NO2, or -CN; (11) R4 is selected from: hydrogen, C1-6 alkyl, aryl, alkylaryl, said aryl and alkylaryl groups being optionally substituted with 1 to 3 substituents selected from: halogen, -CF3, -OCF3, -OH, -N (R45 ) 2, -CO2R45, -C (O) N (R45) 2, or -CN, where R45 is as defined above; (12) R5 is selected from hydrogen, C1-6 alkyl, -C (O) R4, -C (O) 2R4, or -C (O) N (R4) 2, where each R4 is independently selected, and R4 is as defined above; (13) or R4 and R5 taken together with the nitrogen atom to which they are attached form a 5- or 6-membered heterocycloalkyl ring; (14) R6 is selected from: alkyl, aryl, alkylaryl, halogen, hydroxyl, lower alkoxy, -CF3, CF3O-, -NR4R5, phenyl, -NO2, -CO2R4, -CON (R4) 2, where each R4 is the same or different, or -CN; (15) R12 is selected from: alkyl, hydroxyl, alkoxy or fluorine; (16) R3 is selected from: alkyl, hydroxyl, alkoxy or fluorine; (17) a is 0 to 2; (18) b is 0 to 2; (19) c is 0 to 2; (20) e is 0 to 5; (21) m is 1 or 2; (22) n is 1, 2 or 3; and (23) p is 1, 2 or 3, with the proviso that when M3 and M4 are both nitrogen, then p is 2 or 3. Pharmaceutical compositions comprising the compounds of the formula (1) are also described. Also described are pharmaceutical compositions comprising the compounds of the formula (1) for treating various diseases or conditions, such as for example allergy, allergy-induced airway responses, and congestion (nasal congestion) using the compounds of the formula ( 1) in combination with an H1 receptor antagonist. Also described are the use of said compounds for the manufacture of medicaments methods for treating various diseases or conditions, such as, for example, allergy, allergy-induced airway responses, and congestion (eg, nasal congestion), using the compounds of the formula (1). |
| priorityDate | 2000-10-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 83.