| abstract |
Compounds derived from imidazole of general formula 1 wherein A is phenyl, pyridin-2-yl, pyridin-3-yl, or piperidin-1-yl; R1 and R2 are independently of each other hydrogen, halogen, lower alkyl, cycloalkyl, lower alkenyl, trifluoro-methyl, -O-trifluoromethyl, S-trifluoromethyl, S-lower alkyl, lower alkoxy, -CHF2, -C (lower alkyl ) F2, -OCHF2, phenyl, nitro, benzyloxy, hydroxyl or amino or are together with the carbon atoms to which they are attached in any of the adjacent compositions -CH = CH-CH = CH-, -CH = CH-CH = N-, - (CH2) 3-, -O-CH2-O-, -O-CF2-O-, -CH2-O-CH2-, CH2CH2-O-; R3 is hydrogen, lower alkyl, cycloalkyl, phenyl, S-lower alkyl, amino, lower alkyl-amino, -NHC (O) -alkyl or hydroxy-lower alkyl; R4 and R5 are independently of each other hydrogen or lower alkyl or are next to the carbon atom to which they are attached - (CH2) 4-; R6 and R6 'are independently of each other hydrogen or lower alkyl; X is -N <or; Y is = N-, -NH-, -N = CH- or -CH =; Z is -CR7 =, -N =, -NR7-, -N = CR7-, = CH-N = C (R7) - o = N-CH = CH-; R7 is hydrogen, -CH2OH or lower alkyl; n is 0, 1 or 2: m is 0 or 1; and the dotted line can be a link; and pharmaceutically acceptable acid addiction salts thereof. These compounds have a good affinity to the selective blockers of a subtype of NMDA receptor (N-methyl-D-aspartate), which has a key function in the modulation of neuronal activity and plasticity that makes it develop a key role in the mediation of processes underlying the development of the CNS as well as in learning and memory formation. These compounds are therefore suitable in the control or treatment of diseases related to this receptor. A medicine that contains one or more of the compounds, a process for the preparation of the compounds and the use of the compounds. |