| abstract |
Metallo protease inhibitor compounds of formula (1): in which R1 represents a halogen atom, a linear or branched (C1-6) alkyl group or a linear or branched (C1-6) alkoxy group, X represents an atom of oxygen, a sulfur atom or an NR group in which R represents a hydrogen atom or a linear or branched (C1-6) alkyl group, A represents any of the groups (2), in which Ra represents an atom of hydrogen, a halogen atom, a linear or branched (C1-6) alkyl group; (3) in which Rb, Rc are identical or different, represents a hydrogen atom or a linear or branched (C1-6) alkyl group, and n is 0, 1 or 2; or (4), its isomers, N-oxides and its addition salts with an acid or with a pharmaceutically acceptable base. These compounds have proven to be more powerful than those described in the literature, which makes them therefore potentially useful for the treatment of cancers of rheumatic diseases, such as osteoarthritis and rheumatoid arthritis, of arteriosclerosis etc. Its preparation procedure and the pharmaceutical compositions that contain them. |