http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-035400-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f608437b78674d77bd371f635a364d56 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-522 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-505 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-10 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K- http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P- http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D- http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P13-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P7-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-519 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-505 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-12 |
| filingDate | 2001-11-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_758093d43a46026dc5a7c21d7ad72b66 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9375a19c4d86571de3b7ce3cda5235f8 |
| publicationDate | 2004-05-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-035400-A1 |
| titleOfInvention | AN ADENOSINE A1 RECEIVER ANTAGONIST COMPOUND, A PHARMACEUTICAL COMPOSITION THAT INCLUDES IT AND A PROCESS TO PREPARE IT |
| abstract | An adenosine A1 receptor antagonist compound is described, characterized by the formula (1): wherein R1 and R2 are independently selected from the group consisting of: a) hydrogen, b) alkyl, alkenyl or alkynyl, wherein said alkyl, alkenyl or alkynyl is or is not substituted or functionalized with one or more substituents selected from the group consisting of hydroxy, alkoxy, amino, alkylamino, dialkylamino, heterocyclyl, acylamino, alkylsulfonylamino and heterocyclylcarbonylamino; and c) aryl or substituted aryl; R3 is selected from the group consisting of: (a) a bicyclic, tricyclic or pentacyclic group selected from the group consisting of the group of formulas (2) wherein the bicyclic, tricyclic or pentacyclic group is or is not substituted or functionalized with one or more substituents selected from the group consisting of: (i) alkyl, alkenyl and alkynyl, wherein each alkyl, alkenyl or alkynyl group is or is not substituted or functionalized with one or more substituents selected from the group consisting of (alkoxycarbonyl) aralkylcarbamoyl, (amino) (R5 ) acihidrazinilcarbonilo, (amino) (R5) aciloxicarboxi, (hydroxy) (carboalkoxy) alkylcarbamoyl, acilaminoalquilamino, acyloxy, aldehyde, alkenoxy, alkenylamino, alkenylsulfonylamino, alkoxy, alkoxycarbonyl, alkoxycarbonylalkylamino, alkoxycarbonylamino, alcoxicarbonilaminoaciloxi, alkoxycarbonylaminoalkylamino, alkylamino, alkylaminoalkylamino, alkylcarbamoyl, alkylphosphono , alkylsulfonylamino, alkylsulfonyloxy, amino, aminoacyloxy, amin oalquilaralquilcarbamoilo, aminoalquilcarbamoilo, aminoalquilheterocicloalquilcarbamoilo, aminocicloalquilalquilcicloalquilcarbamoilo, aminocicloalquilcarbamoilo, aralkoxycarbonyl, aralkoxycarbonylamino, arilheterociclo, aryloxy, arylsulfonylamino, arylsulfonyloxy, carbamoyl, carbonyl, cyano, cianoalquilcarbamoilo, cycloalkylamino, dialkylamino, dialkylaminoalkylamino, dialquilaminoalquilcarbamoilo, dialkylphosphono, haloalkylsulfonylamino, halogen, heterocyclyl, heterocyclylalkylamino, heterociclilcarbamoilo, hydroxy, hydroxyalkylsulfonylamino, oximino, phosphate, phosphono, -R5 R5-alkoxy, R5-alkyl (alkyl) amino, R5-alkylalkylcarbamoyl, R5-alkylamino, R5-alkylcarbamoyl, R5-alkylsulfonyl, R5-alkylsulfonylamino, R5-alkylthio heterocyclylcarbonyl, substituted aralkylamino, substituted arylcarboxyalkoxycarbonyl, substituted arylsulfonylaminoalkylamino, substituted heteroarylsulfonylamino, substituted heterocycle, substituted heterocyclylaminoalkylamino, heterocyclylsul substituted phylamino, sulfoxyacylamino, thiocarbamoyl, trifluoromethyl; and (ii) (alkoxycarbonyl) aralquilcarbamoilo, (amino) (R5) acilhidrazinilcarbonilo, (amino) (R5) aciloxicarboxi, (hydroxy) (carboalkoxy) alkylcarbamoyl, acilaminoalquilamino, acyloxy, aldehydo, alkenoxy, alkenylamino, alkenylsulfonylamino, alkoxy, alkoxycarbonyl, alkoxycarbonylalkylamino alkoxycarbonylamino, alcoxicarbonilaminoaciloxi, alkoxycarbonylaminoalkylamino, alkylamino, alkylaminoalkylamino, alkylcarbamoyl, alkylphosphono, alquilsufonilamino, alkylsulfonyloxy, amino, aminoacyloxy, aminoalquilaralquilcarbamoilo, aminoalquilcarbamoilo, aminoalquilheterociclilalquilcarbamoilo, aminocicloalquilalquilcicloalquilcarbamoilo, aminocicloalquilcarbamoilo, aralkoxycarbonyl, aralkoxycarbonylamino, arylheterocyclyl, aryloxy, arylsulfonylamino, arylsulfonyloxy, carbamoyl, carbonyl, cyano , cyanoalkylcarbamoyl, cycloalkylamino, dialkylamino, dialkylaminoalkylamino, dialkylaminoalkylcarbamoyl, dialkylphosphono, haloalkylsulfonylamino, halogen, heterocyclyl, heterocyclyl uylamino, heterocyclylcarbamoyl, hydroxy, hydroxyalkylsulfonylamino, oximino, phosphate, phosphorus, -R5 R5-alkoxy, R5-alkyl (alkyl) amino, R5-alkylalkylcarbamoyl, R5-alkylamino, R5-alkylcarbamoyl, R5-alkylsulfonyl, R5-alkylsulfonyl, R5-alkylsulfonyl, R5-alkylsulfonyl, R5-alkylsulfonyl, R5-alkylsulfonyl, R5-alkylsulfonyl, R5-alkylsulfonyl, R5-alkylsulfonyl, R5-alkylsulfonyl, R5-alkylsulfonyl, R5-alkylsulphonylson alkylthio, R5-heterocyclylcarbonyl, substituted aralkylamino, substituted arylcarboxyalkoxycarbonyl, substituted arylsulfonylaminoalkylamino, substituted heteroarylsulfonylamino, substituted heterocycle, substituted heterocyclylaminoalkylamino, sulfoxyacylamino, thiocarbamoyl, trifluoromethyl; R4 is selected from the group consisting of hydrogen, C1-4 alkyl, (C1-4 alkyl) -CO2H and phenyl, wherein the groups C1-4 alkyl, (C1-4 alkyl) -CO2H and phenyl are or are not substituted or functionalized with one to three substituents selected from the group consisting of halogen, -OH, OMe, -NH2-NO2 benzyl and benzyl functionalized with one to three substituents selected from the group consisting of halogen, -OH, OMe, -NH2 and -NO2, R5 is selected from the group formed by - (CR1R2) nCOOH, -C (CF3) 2OH, -CONHNHSO2CF3, -CONHOR4, -CONHSO2R4, -CONHSO2NHR4, -C (OH) R4PO3H2, -NHCOCF3, -NHCONHSO2R4, -NHPO3H2, NHSO2R4, -NHSO2NHCOR4 , -OPO3H2, -OSO3H, -PO (OH) R4, -PO3H2, -SO3H, -SO2NHR4, -SO3NHCOR4, -SO3NHCONHCO2R4 and the following group of formulas (3); n = 0, 1, 2, or 3; A is selected from the group consisting of -CH = CH, - (CH) m- (CH) m, CH = CH-CH2 and -CH2-CH = CH; m = 1 or 2; X is O or S; Z is selected from the group consisting of a simple ligation, -O-, (CH2) n-, -O (CH2) 1-2-, CH2OCH2-, - (CH2) 1-2O-, and R6 is selected from the group formed by hydrogen, alkyl, acyl, alkylsulfonyl, aralkyl, substituted aralkyl, substituted alkyl, and heterocyclyl; and R7 is selected from the group consisting of: a) hydrogen; b) alkyl, alkenyl with not less than 3 carbons, or alkynyl with not less than 3 carbons, wherein said alkyl, alkenyl or alkynyl is or is not substituted or functionalized with one or more substituents selected from the group consisting of hydroxy, alkoxy, amino , alkylamino, dialkylamino, heterocyclyl, acylamino, alkylsulfonylamino and heterocyclylcarbonylamino; c) aryl or substituted aryl; and d) alkylaryl or aryl substituted with alkyl. The invention further provides a pharmaceutical composition that includes the above compound and a process for preparing it. |
| priorityDate | 2000-12-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 59.