| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b8be6a6c990669567cc455d32b00535e |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D489-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D489-08 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B61-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D489-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D489-02 |
| filingDate |
2002-08-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7318186e8259afa93675cc3a8236bb23
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6599801b36fc4da1bea6d70eb81d4df9 |
| publicationDate |
2004-05-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
AR-035289-A1 |
| titleOfInvention |
OXIDATION C-14 OF MORFINA DERIVATIVES |
| abstract |
A process for the preparation of a 14-hydroxymorphorphinone derivative of formula (1) which comprises reacting the compound of formula (2) with a cobalt oxidant, in the presence of a mild base and air or oxygen as the co-oxidant; wherein R 1 is C 1-7 alkyl optionally substituted with one or more chlorines, butenyl, benzyl, phenyl or naphthyl; and R2 is benzyl or benzyl substituted with one or more C1-6 alkoxy groups or benzyl substituted with one or more halogens. The process is very suitable for the production of noroximorfinone. |
| priorityDate |
2001-08-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |