| titleOfInvention |
COMPOSITE OF 1, 2, 3, 4, 4A, 5, 6, 7, 8, 8 A-DECAHYDROISOQUINOLINE, ITS USE TO PREPARE A PHARMACEUTICAL COMPOSITION, SUCH PHARMACEUTICAL COMPOSITION AND PROCEDURE TO PREPARE SUCH COMPOUND |
| abstract |
A compound of formula (1) wherein Z represents a sulfur or oxygen atom; R1 represents hydrogen, CN, (C1-4) alkyl -CO2H, CO2H or tetrazolo; R2 represents hydrogen, halo, aryl, substituted aryl, CO2H, tetrazolo, C1-4 alkyl, C1-4 alkylaryl, heterocycle, substituted heterocycle, CF3, NHR3, or -OR4; R3 represents hydrogen, C1-4 alkyl, (C1-4) alkylaryl or aryl; R4 represents (C1-6) alkyl, (C1-4) alkylaryl, (C1-4) alkyl-heterocycle, (C1-4) alkyl (C3-10) cycloalkyl, (C1-4) alkyl (aryl (substituted), aryl or heterocycle; and W, X and Y each independently represents hydrogen, halo, (C1-6) alkyl, (C1-4) alkoxy, aryl, substituted aryl, CO2H, CO (NH2), CF3, NH-aryl, NH2 , or NO2, or optionally X and R2 together, or W and X together, or Y and R2 together, together with the carbon atoms to which they are attached, form a benzo-fused group; with the proviso that when Z is sulfur, then R1 is hydrogen, CO2H, or tetrazolo, R2 is hydrogen, halo, (C1-4) alkyl, or CO2H, and W, X and Y are each hydrogen, halo (C1-6) alkyl, CO2H or CN (NH2); or a pharmaceutically acceptable salt or prodrug thereof.In another embodiment, the use of said compound of formula (1) is provided for the preparation of a pharmaceutical composition useful in a method for treating or preventing a neurological disease , or state n Eurodegenerative, which comprises administering to a patient in need thereof an effective amount of a compound of the Formula (1) or a pharmaceutically acceptable salt or prodrug thereof. More specifically, said compound of formula (1) or a pharmaceutically acceptable salt or prodrug thereof, is useful for treating or preventing pain or migraine. In addition, pharmaceutical compositions of compounds of the formula (1), including pharmaceutically acceptable salts, prodrugs and hydrates thereof, comprising a compound of the formula (1) in combination with a pharmaceutically acceptable carrier, diluent or excipient are provided. Intermediates and procedures for the synthesis of the compounds of the formula (1) are also provided. |