| abstract |
A process for compacting with cylinders and manufacturing a pharmaceutical formulation comprising the steps of adding sodium phenytoin to a bowl of a mixer and adding at least one excipient to the tank. The mixture is homogenized and transferred to a cylinder compactor in which pressure is applied to the mixture of sodium phenytoin and excipient. Next, the resulting compacted material is pissed into a granulate, which is homogenized a second time and which is suitable for further processing in a dosage form. Preferably, the excipients include magnesium stearate, sugar, lactose monohydrate and talc. In an alternative embodiment, talc is added immediately before homogenizing the granulate a second time. |