http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-034309-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c7ad58d3c0b071069a8ee0cb8c8ba2e8 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D271-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D271-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D498-04 |
| filingDate | 2002-04-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2004-02-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-034309-A1 |
| titleOfInvention | PHENYL PHONYLAMINOPHENYLAMINE DERIVATIVES, PROCEDURE FOR PREPARATION, MEDICATIONS AND THE USE OF SUCH DERIVATIVES FOR THE PREPARATION OF ANTIVIRAL MEDICINES |
| abstract | Phenylsulfonylaminophenylamine derivatives, comprising compounds of general formula (1), in which: R2 and R3 are the same or different and represent hydrogen, hydroxyl, halogen, nitro, cyano, trifluoromethyl, trifluoromethoxy, C1-6 alkyl, C1-6 alkoxy or they represent a group of formulas (2) or (3) in which R5, R6 and R7 are the same or different and each represent hydrogen or C1-6 alkyl, which may be substituted on its part with one or two substituents selected from the group consisting of hydroxyl, halogen, cyano, trifluoromethyl and trifluoromethoxy; A represents a 5- or 6-membered heteroaryl linked through a C atom with the adjacent phenyl ring, with 1 to 3 heteroatoms selected from the group consisting of N, O and S; R1 represents C6-10 aryl, 5-10 membered heteroaryl or 5-10 membered heterocyclyl, each with 1 to 3 heteroatoms selected from the group consisting of N, O and S, and R1 may be substituted with up to 3 substituents selected from the group consisting of hydroxyl, amino, mono- (C1-6) alkyl, dialkyl (C1-6) amino, halogen, nitro, cyano, oxo, C1-6 alkyl, which may be substituted on the other hand with amino or hydroxyl, alkoxy C1-6, phenyl, 5- or 6-membered heterocyclyl with up to 2 heteroatoms selected from the group consisting of N, O and S, 5- or 6-membered heteroaryl with one or more heteroatoms selected from the group consisting of N, O and S , -C (O) -O-R8, -C (O) -NR9R10, -NH-C (O) R11, -NH-C (O) -C- (O) -R12 and -NH-SO2-R13 ; wherein R8, R9 and R10 are the same or different and each represent hydrogen or C1-6 alkyl; or R9 and R10 together with the nitrogen atom to which they are attached, form a 5- or 6-membered heterocycle containing another nitrogen or oxygen heteroatom and which may be substituted 1 to 2 times with substituents the same or different from the group consisting C1-4 alkyl, which is optionally substituted with hydroxyl or amino, amino, hydroxyl, C1-4 alkoxy, oxo, carboxyl and with (C1-4) alkoxycarbonyl; R11 and R12 are the same or different and each represent trifluoromethyl, C1-6 alkoxy, hydroxy or C1-6 alkyl, which is optionally substituted 1 or 2 times with the same or different substituents of the group consisting of amino, (C1-6 alkoxy) ) carbonylamino, mono-acyl (C1-6) amino, hydroxyl, amidino, guanidino, (C1-6) alkoxycarbonyl, carboxyl and phenyl; and R13 represents C1-6 alkyl or C1-6 aryl, which may each be substituted with halogen, amino, hydroxyl, C1-4 alkoxy or C1-4 alkyl; R4 represents C1-6 alkyl, which may be substituted up to 3 times with the same or different substituents of the group consisting of amino, hydroxyl, halogen, C1-6 alkoxy, (C1-5) alkanoyl, oxy and phenyl, which in turn is optionally substituted 1 or 2 times with substituents the same or different from the group consisting of halogen, nitro, cyano, amino and hydroxyl; or represents C3-7 cycloalkyl, which may be substituted up to 3 times with substituents the same or different from the group consisting of amino, hydroxyl, halogen, C1-6 alkoxy and C1-6 alkyl, which in turn is optionally substituted up to 3 times with substituents the same or different from the group consisting of amino, hydroxyl, halogen and C1-6 alkoxy; or represents C6-10 aryl that is optionally substituted 1 or 2 times with substituents the same or different from the group consisting of halogen, nitro, cyano, amino and hydroxyl; and in which X represents oxygen or sulfur; and wherein the nitrogen-containing heterocycles may also be present in the form of N-oxides; as well as its tautomers, stereoisomers, stereoisomeric mixtures and pharmacologically acceptable salts; as well as procedures for its preparation and its use for the preparation of medications as antiviral agents, especially against cytomegalovirus. |
| priorityDate | 2001-04-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 40.