http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-034015-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6572ff5df928fd17340eb2a8cb6d8502 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D233-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4164 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C317-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-454 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-57 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4409 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D233-61 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4406 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D233-58 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D233-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C317-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-417 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4164 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D233-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4178 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-36 |
| filingDate | 2002-01-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_66c8a2986ce4f83135833b5459084446 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e41875f374d14168a56256a682284db8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1febfc29e18efde7dbf3dc0953029dc3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_338ace531602bdce3deb3ba08f38a270 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_59cc2f33bde9d86ebfdabac39fc6b5ea http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b759896ddfde2a6a37d764b800091038 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_658b2627a3b552d6889b7cf5bfbcc622 |
| publicationDate | 2004-01-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-034015-A1 |
| titleOfInvention | CYCLHEPTENE COMPOUNDS, PROCEDURE FOR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING IT |
| abstract | Compounds of formula (1) in which: X represents a bond or a group selected from alkylene, CO, S (O) n, * -S (O) n-A1-, * -CO-A1-, -A1- S (O) n-A'1- and -A1-CO-A'1-, (where A1 and A'1, equal or different, represent an alkylene group and n is 0, 1 or 2), indicating the symbol '' * '' the point of attachment of these groups to cycloheptene; Y represents an aryl, heteroaryl, cycloalkyl or heterocycloalkyl group, each of these groups being unsubstituted or substituted by one or more R8 groups, the same or different; R1, R2, R3 and R4 each independently of the others represents a hydrogen atom or an aryl, heteroaryl, cycloalkyl or heterocycloalkyl group, each of these groups being unsubstituted or substituted by one or more R8 groups, the same or different; or R1, R2 ,, R3 and R4, taken in pairs, together form a bond; or R1 and R2, or R2 and R3, or R3 and R4, taken in pairs with the carbon atoms to which they are attached, form a fused benzene ring or a partially unsaturated or fused aromatic heterocycle, which has 5 or 6 members of the ring and containing 1 or 2 heteroatoms selected from nitrogen, oxygen and sulfur, it being understood that only one ring can be fused to the 7-member structure; T represents a group -CH (R5) -, -N (R5) - or * -N (R5) CO-, (where R5 represents a hydrogen atom or an alkyl, aryl, heteroaryl, aryl or heteroarylalkyl group, being each of these groups not substituted or substituted by one or more R7 groups, the same or different), the symbol '' * '' indicating the point of attachment of the group to cycloheptene; V represents a hydrogen atom or an aryl or heteroaryl group, each of those groups being unsubstituted or substituted by one or more R7 groups, the same or different; A2 represents a group [C (R6) (R6 ')] p, where p is 0, 1, 2, 3 or 4 when T represents a group -CH (R5) - or * -N (R5) CO-, op is 1, 2, 3 or 4 when T represents a group -N (R5) -; and R6 and R'6, which may be the same or different, represent a hydrogen atom or an alkyl, alkenyl, alkynyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted heterocycloalkyl, optionally substituted arylalkyl, optionally substituted heteroarylalkyl or optionally heterocycloalkylalkyl substituted, an R9 group or an alkyl group substituted by an R9 group (where R9 represents a group -OR5, -N (R5) (R'5), -S (O) mR5, -CON (R5) (R ' 5), -N (R5) COR'5, -N (R5) SO2R'5, -SO2N (R5) (R'5) or -N (R5) COO (R'5), where m 0, 1 or 2 and R'5 may have any of the meanings of (R5); R7 represents a halogen atom or an alkyl, alkoxy, hydroxy, mercapto, alkylthio, cyano, amino group (optionally substituted by one or two alkyl groups), nitro , carboxy, alkoxycarbonyl, aminocarbonyl (optionally substituted by one or two alkyl groups), carbamoyl, substituted or unsubstituted aryl, substituted or unsubstituted arylalkyl C, substituted or unsubstituted heteroaryl, substituted or unsubstituted heteroarylalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkylalkyl, substituted or unsubstituted heterocycloalkyl or substituted or unsubstituted heterocycloalkylalkyl; R8 represents a halogen atom, or an oxo, hydroxy, cyano, nitro, carboxy, alkoxycarbonyl or perhaloalkyl group or a group -U-R80 or -A80-U-R80 (where A80 represents an alkylene group; U represents a bond , an oxygen atom or a group selected from NH, S (O) m, NHCO, SO2NH and NHSO2, with m 0, 1 or 2, and R80 is a group selected from alkyl, aryl, arylalkyl, heteroaryl and heteroarylalkyl); understanding that; the term "alkyl" denotes a linear or branched group containing C1-6; the term "alkylene" denotes a linear or branched bivalent group containing C1-6; the term "cycloalkyl" denotes a saturated cyclic group containing C3-8; the term "heterocycloalkyl denotes a saturated or partially unsaturated cyclic group having 5 to 7 ring members and containing 1 to 3 heteroatoms selected from nitrogen, oxygen and sulfur; the term "aryl" denotes a phenyl or naphthyl group; the term "heteroaryl" denotes a mono- or bi-cyclic group that is aromatic or that contains at least one aromatic ring, has 5 to 11 ring members and contains 1 to 5 heteroatoms selected from nitrogen, oxygen and sulfur; the term "substituted" applied to the terms "aryl", "heteroaryl", "cycloalkyl" and "heterocycloalkyl" means that these groups can be substituted by one or more selected or different groups selected between cyano, alkylcarbonyl, aminocarbonyl (optionally substituted by one or two alkyl groups) and halogen atoms; ; the term "substituted" applied to the terms "arylalkyl", "heteroarylalkyl", "cycloalkylalkyl" and "heterocycloalkylalkyl" means that the cyclic half of those groups can be substituted by one or more groups same or different selected from oxo, cyano alkylcarbonyl, aminocarbonyl (optionally substituted by one or two alkyl groups) and halogen atoms; their enantiomers, diastereoisomers and addition salts thereof with a pharmaceutically acceptable acid or base. Medicines. |
| priorityDate | 2001-01-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 64.