| abstract |
Intermediate compounds for preparing arylsulfonamides and analogs comprising the general formula (XV), R48-SO2- (CH2) hU- (CH2), - CR49R50-CF2-R51 in which R48 is a leaving group, U is oxygen or a bond simple, R48 and R50 are the same or different and mean H, F, Cl or CF3, R51 is H, F, Cl, Br, h is a number of 1 or 2 and i is a number 0 or 1, except for the compounds where U is a single bond, R49 and R50 are equal and mean H or F, and R51 means F, and with the exception of compounds in which U is oxygen, R49 or R50 means Cl, and i means 0, useful for the prophylaxis and treatment of neurodegenerative diseases, especially for the treatment of cerebral apoplexy and head-brain trauma. |