| abstract |
Use of substituted 4-amino-1-phenylbutane-2-ol compounds of the general formula 1, in which A represents an aryl or heteroaryl radical, R1 and R2 may be the same or different from each other and represent a C1-6 radical -alkyl, preferably C1-3-alkyl, or R1 and R2 together form a (CH2) 2-6 cycle which may also be substituted with phenyl, R3 and R4 may be the same or different from each other and represent a C1-6 radical -alkyl, preferably C1-3-alkyl, an aryl radical or an aryl radical linked through a C1-3-alkylene radical or the radicals R3 and R4 together form a group (CH2) 3-6 or CH2CH2OCH2CH2, R5, R6, R7 may be the same or different from each other and represent H, F, Cl, Br, I, CF3, OR8, SO2CH3, SO2CF3, phenyl, CN, NO2 or a C1-6 alkyl radical, R8 represents H, a C1 radical -6-alkyl, preferably C1-3-alkyl, or an aryl or heteroaryl radical linked through a C1-3-alkylene radical, in the form of its racemates, enantiomers, diastereomers or bases or corresponding salts with physiologically tolerable acids as regulators for the nociceptin / orphanin FQ receptor ligand system ORL1 and for the preparation of medicaments. |