http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-031259-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0efa077d881a96aeb1e29b21ef1bbb58 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C51-15 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F5-025 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D309-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F7-0827 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C37-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C37-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C39-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C65-05 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C45-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F7-081 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C47-565 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C47-565 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C65-05 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D309-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F5-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C37-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C37-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C49-825 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F7-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C39-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C51-15 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C45-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C45-60 |
| filingDate | 2001-08-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2003-09-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-031259-A1 |
| titleOfInvention | DERIVATIVES OF 4- (TRIFLUOROMETIL) PHENOL AND DERIVATIVES OF 4- (TRIFLUOROMETIL) PHENYL 2-TETRAHYDROPIRANIL ETER AND PROCEDURES FOR PREPARATION |
| abstract | A process that is applied for the preparation of compounds of the general formula (1) wherein: R is hydrogen or tetrahydropyran-2-yl; X is B (OH) 2, B (OR1) 2, B (Oaril) 2, B (OR1) (Oaril), CHO, COR1, CO (aryl), COOH, COOR1, SIR31, Si (aril) 3, OH , SR1, S (aryl), Cl, Br, I; Y is H, B (OH) 2, B (OR1) 2, B (Oaril) 2, B (OR1) (Oaril), CHO, COR1, CO (aryl), COOH, COOR1, SIR31, Si (aril) 3 , OH, SR1, S (aryl), Cl, Br, I; R1 independently of one another is C1-8 alkyl; aryl independently of each other is phenyl, naphthyl, R1-C6H4 or R1O-C6H4; which comprises reacting the compound of the formula (2) 4- (trifluoromethyl) phenyl 2-tetrahydropyranyl ether in the presence of a base with an EX electrophile or a combination of EX and EY electrophiles where X and Y have the meanings indicated above. . The base used can be an organolithium compound. The reaction can be performed in the presence of an amine, preferably a chelation amine is used. Preferably, the reaction is carried out at a temperature of -100 to +100 degree C and a pressure of 1.02 to 203.94 kg / cm2. A 2-substituted derivative of 4- (trifluoromethyl) phenol and 4- (2-trifluoromethyl) phenyl 2-tetrahydropyranyl ether having the structure of formula (3) wherein: R is hydrogen or tetrahydropyran-2-yl; and if R is hydrogen, X is B (OH) 2, B (OR1) 2, B (Oaril) 2, COOR1, SiR13, Si (aryl) 3, SR2, S (aryl) or I; R1 independently of one another is C1-8 alkyl; R2 independently of one another is C2-8 alkyl; aryl is phenyl, naphthyl, R1-C6H4 or R1O-C6H4; if R is tetrahydropyran-2-yl, X is B (OH) 2, B (OR1) 2, B (Oaril) 2, CHO, COR1, CO (aryl), COOH, COOR1, SiR13, Si (aryl) 3, OH, SR1, S (aryl), Cl, Br, I; R1 independently of one another is C1-8 alkyl; aryl independently of each other is phenyl, naphthyl, R1-C6H4 or R1O-C6H4. A 2,5-disubstituted derivative of 4- (trifluoromethyl) phenol and 4- (2-trifluoromethyl) phenyl 2-tetrahydropyranyl ether having the structure of formula (1) wherein R, X, R1 and aryl are as defined for 1); and Y regardless of X is B (OH) 2, B (OR1) 2, B (Oaril) 2, B (OR1) (Oaril), CHO, COR1, CO (aryl), COOH, COOR1, SiR13, Si (aril ) 3, OH, SR1, S (aril), Cl, Br, I. |
| priorityDate | 2000-08-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 38.