| abstract |
New and known pyrazole derivatives, a process for their preparation, pharmaceutical compositions and the use of such compounds in medicine. In particular, the compounds of formula I are inhibitors of the reverse transcriptase enzyme of the human immunodeficiency virus that is involved in viral replication. Accordingly, the compounds of this invention can be used favorably as therapeutic agents for human immunodeficiency virus (HIV) mediated processes. Specifically, the use of compounds of formula I is described wherein R1 is an optionally substituted C1-12-alkyl, C3-8-cycloalkyl, acyl, C1-4-alkylsulfonyl, optionally substituted phenylsulfonyl, aryl, heterocyclyl or C1-4-alkyl optionally substituted with phenyl; R2 is optionally substituted aryl or phenyl; R3 is C1-12-alkyl or C1-4-alkoxy-C1-4-alkyl; A indicates a group selected from CH2- (aryl-C1-4-alkylamino), CH2- (aryl-C1-4-alkoxy), CH2- (heterocyclyl-C1-4-alkoxy), C1-4-alkyl substituted with aryl optionally substituted or with optionally substituted heterocyclyl; or A indicates a group of formula CH2-U-heterocyclyl, wherein U represents O, S or NR ", where R" is hydrogen or C1-4-alkyl; or A indicates a group of formula CH (V) Z, where V represents OH or F, and where Z represents aryl or heterocyclyl; or A indicates a group of formula CH = CHW, wherein W represents optionally substituted aryl or optionally substituted heterocyclyl; X represents S or O; for the treatment of diseases mediated by the human immunodeficiency virus (HIV) or for the preparation of a medicament for said treatment. |