http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-030143-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5b273142130d764e4c9ec79fb0e21ea2 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-07 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2603-88 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2601-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2601-02 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C237-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C233-37 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C211-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C233-78 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C211-27 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C279-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C279-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C257-14 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C233-37 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C279-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C211-27 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C233-78 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C257-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C279-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C211-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C237-22 |
| filingDate | 1999-06-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2003-08-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-030143-A1 |
| titleOfInvention | 1,4-SUBSTITUTED CYCLOHEXYL COMPOUNDS, USES OF SUCH COMPOUNDS FOR THE MANUFACTURE OF MEDICINES, ISOTOPICALLY LABELED COMPOUNDS, DIAGNOSTIC AGENT, PHARMACEUTICAL COMPOSITIONS, PROCESS FOR THE PREPARATION OF SUCH COMPOSIUMS IN THEIR COMPOSITE USE |
| abstract | 1,4-substituted cyclohexyl compounds comprising formula (1) wherein A is a compound of formula (2) or (3), wherein R2 and R3 are as defined below; Z is (CH2) m or a carbonyl group; m and n are each and independently an integer between 0-3, and one or more of the hydrogens in that type of alkylene chain may optionally be substituted by any of C 1-6 alkyl, C 1-6 alkoxy, or hydroxy; or one or more of the methylene groups may be optionally substituted by a heteroatom such as O, N or S; m and n may not be both 0; Q is selected from any of CH3; of formula (3) wherein R4, R5 and R6 are each and independently selected from any of (i) C6-10 aryl, or (ii) heteroaryl having between 5 and 10 atoms and the heteroatom being selected from any of S , N and O; and wherein the aryl and heteroaryl may be optionally and independently substituted by 1 or 2 substituents Y where each Y is as defined below; (iii) hydrogen; (iv) a straight to branched C1-6 alkyl, C2-6 alkenyl or C2-6 alkynyl; (v) C1-3 alkoxy; (vi) saturated or unsaturated C3-10 cycloalkyl, optionally and independently substituted by one or more aryl groups or heteroaryl groups having between 5 and 10 atoms, the heteroatom (s) being selected from any of S, N and O and wherein the aryl and heteroaryl may optionally and independently be substituted by 1 or 2 substituents Y where each Y is as defined below; (vii) û [(CH2) q-aryl] where q is an integer between 1 û 3, and the aryl can be optionally substituted by 1 or 2 substituents Y, where each Y is as defined below; (viii) û [(CH2) r û heteroaryl] where r is an integer between 1 û 3, and the heteroaryl has between 5 and 10 atoms being the heteroatoms selected from any of S, N and O, optional and independently substituted by 1 or 2 substituents AND as defined below; (ix) û [CH2-O-aryl] where the aryl can be optionally substituted by 1 or 2 substituents Y, where each Y is as defined below; (x) of formula (4) where q is an integer between 1-3, and the aryl is as defined below, optionally substituted by 1 or 2 substituents Y, where each Y is as defined below; R1 is selected from any of (i) a straight or branched C1-6 alkyl, C2-6 alkenyl or C2-6 alkynyl, wherein each alkyl, alkenyl or alkynyl may be optionally substituted by one or more aromatic or heteroaromatic substituents; (ii) C3-7 cycloalkyl, optionally comprising one or more unsaturations and optionally substituted by one of more than C1-6 alkyl, C1-6 alkoxy, hydroxy; or substituted by one or more aryl (s), or heteroaryl (s) having between 5 and 10 atoms and the heteroatom (s) are selected from any of S, N and O and wherein the aryl and heteroaryl can be optionally substituted and independently by 1 or 2 substituents Y where each Y is as defined below; (iii) hydrogen, halogen or C1-6 alkoxy; (iv) C6-10 aryl; (v) having the heteroaryl of 5 to 10 atoms and the heteroatom being selected from any of S, N and O; wherein the aryl and the heteroaryl may be optionally and independently substituted by 1 or 2 Y substituents wherein each Y is as defined below (vi) 9,10-dihydro-9,10-ethanoanthracenyl; (vii) û [(CH2) q-aryl] where q is an integer between 1-3 and the aryl can optionally be substituted by 1 or 2 substituents Y, where each Y is as defined below; (viii) û [(CH2) r-heteroaryl] where r is an integer between 1-3, the heteroaryl having between 5 and 10 atoms and the heteroatom (s) being selected from any of S, N and O, and where the heteroatom (s) may be optionally and independently substituted by 1 or 2 Y substituents, where each Y is as defined below; (ix) û [(CH2) q-aryl-O- (CH2) r-aril] where qyr is each and independently an integer between 1-3; (x) û (CH2) q- [C3-6 cycloalkyl] where q is between 1-2, optionally substituted by 1 or 2 substituents Y where each Y is as defined below; R2 is selected from any of (i) hydrogen; (ii) a straight or branched C1-6 alkyl, C2-6 alkenyl or C2-6 alkynyl wherein each alkyl, alkenyl or alkynyl may be optionally substituted by one or more aromatic or heteroaromatic substituents; (iii) C6-10 arylalkyl, wherein the aryl may be optionally substituted by one or more heteroaryls having between 5 and 10 atoms and the heteroatom being selected from any of S, N and O, and wherein the aryl and heteroaryl they may be optional and independently substituted by 1 or 2 Y substituents where each Y is as defined below; (iv) heteroaryl- (C5-10 alkyl), where the heteroaryl has between 5 and 10 atoms and the heteroatom being selected from any of S, N and O, and wherein the aryl and heteroaryl may be optionally and independently substituted by 1 or 2 substituents Y where each Y is as defined below; (v) C3-10 cycloalkyl optionally comprising one or more unsaturations and optionally substituted by one or more heteroaryls where the heteroaryl has between 5 and 10 atoms and the heteroatom being selected from any of S, N and O; and wherein the aryl and heteroaryl may be optionally and independently substituted by 1 or 2 substituents Y where each Y is as defined below; (vi) C6-10 aryl optional and independently substituted by one or more heteroaryls having between 5 and 10 atoms and the heteroatom (s) being selected from any of S, N and O and wherein the heteroaryl may be optional and independently substituted by 1 or 2 substituents Y where each Y is as defined below; (vii) having the heteroaryl between 5 and 10 atoms and the heteroatom being selected from any of S, N and O; wherein the aryl and heteroaryl may be optionally and independently substituted by 1 or 2 substituents Y where each Y is as defined below; R3 is selected from any of (i) hydrogen; (ii) a straight or branched C1-6 alkyl, C2-6 alkenyl or C2-6 alkynyl wherein each alkyl, alkenyl or alkynyl may be optionally substituted by one or more aromatic or heteroaromatic substituents; (iii) C6-10 arylalkyl, wherein the aryl may optionally be substituted by one or more heteroaryls having between 5 and 10 atoms and the heteroatom being selected from any of S, N and O; and wherein aryl and heteroaryl may be optionally and independently substituted by 1 or 2 substituents Y where each Y is as defined below; (iv) heteroaryl- (C5-10 alkyl), where the heteroaryl has between 5 and 10 atoms and the heteroatom being selected from any of S, N and O, and wherein the aryl and heteroaryl can be optionally and independently substituted by 1 or 2 substituents Y where each Y is as defined below; (v) C3-10 cycloalkyl, optionally comprising one or more unsaturations and optionally substituted by one or more heteroaryls having between 5 and 10 atoms and the heteroatom being selected from any of S, N and O; and wherein the aryl and heteroaryl may be optionally and independently substituted by 1 or 2 substituents Y where each Y is as defined below; (vi) is formula (5) wherein R7, R8, R9, R10 and R11 is each and independently selected from (a) hydrogen; (b) a straight or branched C1-6 alkyl, C2-6 alkenyl or C2-6 alkynyl, wherein each alkyl, alkenyl or alkynyl may be optionally substituted by one or more aromatic or heteroaromatic substituents; (c) C6-10 arylalkyl wherein the aryl may optionally be substituted by one or more heteroaryls having between 5 and 10 atoms and the heteroatom being selected from any of S, N and O; and wherein aryl and heteroaryl may be optionally and independently substituted by 1 or 2 substituents Y where each Y is as defined below; (d) heteroaryl- (C5-10 alkyl), where the heteroaryl has between 5 and 10 atoms and the heteroatom being selected from any of S, N and O, and wherein the aryl and heteroaryl may be optionally and independently substituted by 1 or 2 substituents Y where each Y is as defined below; (e) C3-10 cycloalkyl, optionally comprising one or more unsaturations and optionally substituted by one or more heteroaryls where the heteroaryl has between 5 and 10 atoms and the heteroatom being selected from any of S, N and O, and wherein the aryl and heteroaryl may be optionally and independently substituted by 1 or 2 substituents Y where each Y is as defined below; (f) C6-10 aryl, optionally and independently substituted by one or more heteroaryls having between 5 and 10 atoms and the heteroatom (s) being selected from any of S, N and O and wherein the heteroaryl can be optionally and independently substituted by 1 or 2 substituents Y where each Y is as defined below; or R2 and R3 may optionally form a heterocyclic ring; Y is each and independently selected from any of hydrogen, CH3, - (CH2) p1CF3; halogen; C1-3 alkoxy, hydroxy, -NO2; -OCF3; -CONRaRb, -COORa, -CORa, - (CH2) p2NRaRb, - (CH2) p3CH3, (CH2) p4SORaRb, - (CH2) p5SO2Ra, - (CH2) p6SO2NRa, (alkyl-cycloalkyl) C4-8 where alkyl is C1-2 alkyl and cycloalkyl is C3-6 cycloalkyl; 1 or 2 heteroaryls have between 5 and 10 atoms and the heteroatom (s) being selected from any of S, N and O; and oxides such as N-oxides or sulfoxides; and wherein Ra and Rb are each independently selected from hydrogen, a C1-6 alkyl, C1-6 straight or branched C3-8 cycloalkyl and wherein p1, p2, p3, p4, p5 and p6 each is independently 0 , one |
| priorityDate | 1998-06-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 36.