| abstract |
Benzimidazole derivatives of the general formula (1) in which X represents a nitrogen atom or a carbon atom; and in the case where X represents a nitrogen atom: R3 represents a hydrogen atom or a (C1-4) alkyl group, or does not exist, to give the compounds of formula (1) having a secondary or tertiary amine; R4 represents a hydrogen atom or a (C1-6) alkyl, cycloalkyl (C3-7), heterocycloalkyl (C3-7) group, optionally substituted, heteroaryl- (CH2) p-, heteroarylcarbonyl, phenylcarbonyl, (C1-6 alkylcarbonyl) ), - (CH2) pCOOR, optionally substituted phenylsulfonyl or- (CH2) p-phenyl optionally substituted, and in the case where X represents a carbon atom: R3 represents a hydrogen atom or a group ûNR5R6, -N (R5 ) 3+, -NHCOR7, -CONHR5, COR7, -NHCONH2, -OH or ûCH2OH, R4 represents a hydrogen atom or a group û (CH2) p-phenyl optionally substituted, heteroaryl- (CH2) p- or û (CH2 ) t NR7R8. The symbols R1, R2, R2 ', R, R5, R6, R7, R8, n, m, p, t, have the meanings assigned in the description. Procedure of preparation and application in therapeutics. |