| abstract |
An oxyiminoalkanoic acid derivative that has excellent hypoglycemic and hypolipidemic action and is used for the prevention or treatment of diabetes mellitus, hyperlipidemia, insulin insensitivity, insulin resistance and decreased glucose tolerance. Said compound is represented by formula (1) wherein: R1 is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group; X is a bond, -CO-, -CH (OH) - or a group represented by -NR6- wherein R6 is a hydrogen atom or an optionally substituted alkyl group; n is an integer from 1 to 3; Y is an oxygen atom, a sulfur atom, -SO-, -SO2- or a group represented by -NR7- wherein R7 is a hydrogen atom or an optionally substituted alkyl group; an A ring is a benzene ring that optionally has one to three additional substituents; p is an integer from 1 to 8; R2 is a hydrogen atom, an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group; q is an integer from 0 to 6; m is 0 or 1; R3 is a hydroxyl group, OR8 (R8 is an optionally substituted hydrocarbon group) or NR9R10 (R9 and R10 are the same or different that are selected from a hydrogen atom, an optionally substituted hydrocarbon group, an optionally substituted heterocyclic group and an acyl group optionally substituted or R9 and R10 combine with each other to form a ring); R4 and R5 are the same or different groups that are selected from a hydrogen atom and an optionally substituted hydrocarbon group wherein R4 can form a ring with R2; provided that when R1 is an ethoxymethyl, a C1-3 alkyl, phenyl or p-methoxyphenyl and q = m = 0, R3 is NR9R10; and with the proviso that O- [2-chloro-4- (2-quinolylmethoxy) phenylmethyl] oxime of methyl pyruvate and [2-chloro-4- (2-quinolylmethoxy) phenylmethyl] -2-iminoxypropionic acid are excluded; or a salt thereof. Pharmaceutical composition and agent for controlling retinoid-related receptors that comprise it together with a pharmaceutically acceptable carrier. Use of said compound for the preparation of said medicament. |