http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-029612-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_71499ee5cbc2e0ef0934e4f106318743 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D473-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D473-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D473-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-10 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P13-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D473-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D473-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D473-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P19-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P19-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-10 |
| filingDate | 2000-01-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2003-07-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-029612-A1 |
| titleOfInvention | A 2,6,9-TRISUSTITUTED PURINE OF IKB-ALFA AND CYCLIN DEPENDENT KINASE, USE OF THE SAME FOR THE MANUFACTURE OF A MEDICINAL PRODUCT AND A PHARMACEUTICAL COMPOSITION OF MATERIAL |
| abstract | Purine 2, 6, 9-trisubstituted having the general formula (1), wherein R1 is halogen or R'1-X where X = NH, O, S, S (O2). R'1 is alkyl, heterocyclyl, aryl, heteroaryl, aralkyl, heteroarylalkyl, alkenyl and alkynyl, each having one to 20 carbon atoms, whose alkyl, heterocyclyl, aryl, heteroaryl, aralkyl, heteroarylalkyl, alkenyl and alkynyl are optionally substituted. with from 1 to 3 substituents independently selected from the group consisting of halo, aryl, CF3, heteroaryl, heterocyclyl, R22, SR20, S (O) R21, SO2R21, SO2NR20R23, SO2NR20COR21, SO2NR20, CONR20R23, SO2NR20CO2R21, NR20R21, NR20C23 NR20CO2R21, NR20CONR20R23, N (R20) C (NR20) NHR23, NR20SO2R21, OR20, OCONR20R23, OCONR20SO2R21, OCONR20R23, CN, CO2R20, CONR20R23, CONR20SO2R21 and COR20, R2 is a selected hydrogen or hydrocarbon, heteroaryl, heterocyclic, aryl alkyl, heteroaryl, hydrocarbon heteroaryl, aralkyl, heteroarylalkyl, alkenyl and alkynyl; each has one to 20 carbon atoms, whose alkyl, heterocyclyl, aryl, heteroaryl, aralkyl, heteroarylalkyl, alkenyl and alkynyl are optionally substituted with from 1 to 3 substituents independently selected from the group consisting of halo, aryl, heteroaryl, heterocyclyl , R22, SR20, S (O) R21, SO2R21, SO2NR20R23, SO2NR20COR21, SO2NR20CONR20R23, SO2NR20CO2R21, NR20R23, NR20COR21, NR20CO2R21, NR20CONR20R23, N (R20) C, NR20ON220, OC20ON2, OC20ON2, OC20ON2 , CO2R20, CONR20R23, CONR20SO2R21 and COR20; R3 is a halogen, hydroxyl, thio, alkoxy, alkylthio, alkyl, -NR4R5 or a component having the formula (2), where m = 1-3, n = 1-3, or = 1, 3, y = carbonyl , -NR4R5, hydroxyl, thiol, alkoxy, alkylthiol; R4 and R5 are each independently hydrogen, OR20, NR20R23 or a hydrocarbon selected from the group including alkyl, acyl, heterocyclyl, aryl, heteroaryl, aralkyl, heteroarylalkyl, alkenyl and alkynyl, each having one to 20 carbon atoms, whose alkyl, acyl, heterocyclyl, aryl, heteroaryl, aralkyl, heteroarylalkyl, alkenyl and alkynyl are optionally substituted with from 1 to 3 substituents independently selected from the group consisting of halo, aryl, heteroaryl, heterocyclyl, R22, SR20, S (O ) R21, SO2R21, SO2NR20R23, SO2NR20COR21, SO2NR20CONR20R23, SO2NR20CO2R21, NR20R23, NR20COR21, NR20CO2R21, NR20CONR20R23, N (R20) C (NR20) NHR23, NR20SO2R21, OR20, OCONR20R23, OCONR20SO2R21, OCONR20R23, CN, CO2R20, CONR20R23, CONR20SO2R21 and COR20 ; with the proviso that when Y is carbonyl, Y and R'4 together can be a simple oxygen atom, R4 '' and R5 '' together can be a simple oxygen atom, R4 '' 'and R5' '' ' together they can be a simple oxygen atom, and where when R3 is 2-hydroxyethylamino and R2 is methyl, R1'-X is not amino, 3-methyl-2-butenylamino, benzylamino, or m-hydroxybenzylamino, when R3 is not 2-hydroxyethylamino, when R2 is isopropyl, R1'-X is not benzylamino, m-hydroxybenzylamino, or 3-methylbutylamino, when R3 is 2-hydroxyethylamino and R2 is 2-hydroxyethyl, R1'-X is not benzylamino, and when R3 it is selected from the group consisting of 2-methyl-2-hydroxypropylamino, and 2-dimethylaminoethylamino, and when R2 is methyl, then R1'-X is not benzylamino; R20 is a member selected from the group consisting of H, C1-15 alkyl, C2-15 alkenyl, C2-15 alkynyl, heterocyclyl, aryl and heteroaryl, whose alkyl, alkenyl, alkynyl, heterocyclyl, aryl and heteroaryl are optionally substituted with 1 to 3 substituents independently selected from halo, alkyl, mono- or dialkylamino, alkyl or aryl or heteroaryl amide, CN, O-C1-6 alkyl, CF3, aryl and heteroaryl; R21 is a member selected from the group consisting of C1-15 alkyl, C2-15 alkenyl, C2-15 alkynyl, heterocyclyl, aryl and heteroaryl, whose alkyl, alkenyl, alkynyl, aryl, heterocyclyl and heteroaryl are optionally substituted with 1 to 3 substituents independently selected from the group of halo, heterocyclyl, aryl, heteroaryl, CF3, CN, OR20, SR20, N (R20) 2, S (O) R22, SO2R22, SO2N (R20) 2, SO2NR20COR22, SO2NR20CO2R22, SO2NR20CON ( R20) 2, N (R20) 2, NR20COR22, NR20CO2R22, NR20CON (R20) 2, NR20C (NR20) NHR23, COR20, CO2R20, CON (R20) 2, CONR20SO2R22, NR20SO2R22, SO2NR20CO2R22, OR20, OCONR20SO2R22 R20, C (O) OCH2OC (O) R20 and OCON (R20) 2, and each optional heteroaryl, aryl and heterocyclyl substituent is optionally substituted with halo, alkyl, CF3, amino, mono- or di-alkylamino, alkyl or aryl or heteroaryl amide, NCOR22, NR20SO2R22, COR20, CO2R20, CON (R20) 2, NR20CON (R20) 2, OC (O) R20, OC (O) N (R20) 2, SR20, S (O) R22, SO2R22, SO2N (R20) 2, CN or OR20; R22 is a member selected from the group consisting of C1-15 alkyl, C2-15 alkenyl, C2-15 alkynyl, heterocyclyl, aryl and heteroaryl, whose alkyl, alkenyl, alkynyl, heterocyclyl, aryl and heteroaryl are optionally substituted with 1 to 3 substituents independently selected from halo, alkyl, mono- or dialkylamino, alkyl or aryl or heteroarylamide, CN, O-C1-6 alkyl, CF3, aryl and heteroaryl, and R23 is R21 or H and the use thereof for manufacturing of a medication and a pharmaceutical composition. |
| priorityDate | 1999-02-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 52.