http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-029165-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_173bc2c63b34988699010ba05e5b1376 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01N37-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C255-33 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-57 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-57 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C253-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B61-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C255-33 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D231-36 |
| filingDate | 2000-06-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2003-06-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-029165-A1 |
| titleOfInvention | NITRILE COMPOUNDS OF REPLACED ARILMALONIC ACID AND PROCESS FOR PREPARATION |
| abstract | Process for the preparation of substituted 3-hydroxy-4-aryl-5-oxopyrazoline derivatives of the formula (1) wherein R0 is, each independently of any other, halogen, alkyl of 1 to 6 carbon atoms, alkenyl of 2 to 6 carbon atoms alkynyl of 2 to 6 carbon atoms, haloalkyl of 1 to 6 carbon atoms, cyanoalkyl of 1 to 6 carbon atoms, haloalkenyl of 2 to 6 carbon atoms, cyanoalkenyl of 2 to 6 carbon atoms , haloalkynyl of 2 to 6 carbon atoms, cyanoalkynyl of 2 to 6 carbon atoms, hydroxyl, hydroxyalkyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, nitro, amino, alkylamino of 1 to 6 atoms of carbon, di (alkyl of 1 to 6 carbon atoms) amino, alkylcarbonylamino of 1 to 6 carbon atoms, alkylsulfinylamino of 1 to 6 carbon atoms, alkylaminosulfonyl of 1 to 6 carbon atoms, alkylcarbonyl of 1 to 6 carbon atoms , alkylcarbonyl of 1 to 6 carbon atoms-alkyl of 1 to 6 carbon atoms, alkoxycarbonyl of 1 to 6 carbon atoms-alkyl of 1 to 6 carbon atoms, alkylcarbonyl of 1 to 6 carbon atoms-alkenyl of 2 to 6 carbon atoms, alkoxycarbonyl of 1 to 6 carbon atoms-alkenyl from 2 to 6 carbon atoms, alkylcarbonyl of 1 to 6 carbon atoms-alkynyl of 2 to 6 carbon atoms, alkoxycarbonyl of 1 to 6 carbon atoms-alkynyl of 2 to 6 carbon atoms, alkoxycarbonyl of 1 to 6 atoms of carbon, cyano, carboxyl, phenyl or an aromatic ring containing one or two heteroatoms selected from the group consisting of nitrogen, oxygen and sulfur where the last two aromatic rings may be substituted by alkyl of 1 to 3 carbon atoms , haloalkyl of 1 to 3 carbon atoms, alkoxy of 1 to 3 carbon atoms, haloalkoxy of 1 to 3 carbon atoms, halogen, cyano, or nitro; or R0 together with the adjacent substituents R1, R2, and R3 forms a hydrocarbon bridge of 3 to 6 saturated or unsaturated carbon atoms that may be interrupted by one or two heteroatoms selected from the group consisting of nitrogen, oxygen, and sulfur, and / or may be substituted by alkyl of 1 to 4 carbon atoms; R1, R2, and R3 are each independently of the others, hydrogen, halogen, alkyl of 1 to 6 carbon atoms, alkenyl of 2 to 6 carbon atoms, alkynyl of 2 to 6 carbon atoms, cycloalkyl of 3 to 6 carbon atoms, haloalkyl of 1 to 6 carbon atoms, haloalkenyl of 2 to 6 carbon atoms; alkoxycarbonyl of 1 to 6 carbon-alkenyl atoms of 2 to 6 carbon atoms, alkylcarbonyl of 1 to 6 carbon-alkenyl atoms of 2 to 6 carbon atoms, cyanoalkenyl of 2 to 6 carbon atoms, nitroalkenyl of 2 to 6 carbon atoms, haloalkynyl of 2 to 6 carbon atoms, alkoxycarbonyl of 1 to 6 carbon atoms-alkynyl of 2 to 6 carbon atoms, alkylcarbonyl of 1 to 6 carbon atoms-alkynyl of 2 to 6 carbon atoms, cyanoalkynyl from 2 to 6 carbon atoms, nitroalkynyl of 2 to 6 carbon atoms, halocycloalkyl of 3 to 6 carbon atoms, hydroxyalkyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms-alkyl of 1 to 6 atoms carbon, thioalkyl of 1 to 6 carbon atoms-alkyl of 1 to 6 carbon atoms, cyano, alkylcarbonyl of 1 to 4 carbon atoms, alkoxycarbonyl of 1 to 6 carbon atoms, hydroxyl, alkoxy of 1 to 10 atoms of carbon, alkenyloxy of 3 to 6 carbon atoms, alkynyloxy of 3 at 6 carbon atoms, haloalkoxy of 1 to 6 carbon atoms, haloalkenyloxy of 3 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms-alkoxy of 1 to 6 carbon atoms, mercapto, thioalkyl of 1 to 6 atoms carbon, halothioalkyl of 1 to 6 carbon atoms, alkylsulfinyl of 1 to 6 carbon atoms, alkylsulfonyl of 1 to 6 carbon atoms nitro, amino, alkylamino of 1 to 6 carbon atoms, di (alkyl of 1 to 6 atoms carbon) amino, or phenoxy, wherein the phenyl ring may be substituted by alkyl of 1 to 3 carbon atoms, haloalkyl of 1 to 3 carbon atoms, alkoxy of 1 to 3 carbon atoms, haloalkoxy of 1 to 3 carbon, halogen, cyano, or nitro atoms; R2 may also be phenyl, naphthyl, or a 5- or 6-membered aromatic ring that may contain one or two heteroatoms selected from the group consisting of nitrogen, oxygen and sulfur, wherein the phenyl ring, the ring system of naphthyl and the 5- or 6-membered aromatic ring may be substituted by halogen, cycloalkyl of 3 to 8 carbon atoms, hydroxyl, mercapto, amino, cyano, nitro, or formyl; and / or the phenyl ring, the naphthyl ring system, and the 5- or 6-membered aromatic ring, may be substituted by alkyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, hydroxyalkyl of 1 at 6 carbon atoms, alkoxy of 1 to 6 carbon atoms-alkyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms-alkoxy of 1 to 6 carbon atoms; alkylcarbonyl of 1 to 6 carbon atoms, thioalkyl of 1 to 6 carbon atoms, alkylsulfinyl of 1 to 6 carbon atoms, alkylsulfonyl of 1 to 6 carbon atoms, monoalkylamino of 1 to 6 carbon atoms, di (alkyl of 1 at 6 carbon atoms) amino, alkylcarbonylamino of 1 to 6 carbon atoms, alkylcarbonyl of 1 to 6 carbon atoms (alkyl of 1 to 6 carbon atoms) amino, alkenyl of 2 to 6 carbon atoms, alkenyloxy of 3 to 6 carbon atoms; hydroxyalkenyl of 3 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms-alkenyl of 2 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms-alkenyloxy of 3 to 6 carbon atoms, alkenylcarbonyl of 2 to 6 carbon atoms, thioalkenyl of 2 to 6 carbon atoms, alkenylsulfinyl of 2 to 6 carbon atoms, alkenyl sulfonyl of 2 to 6 carbon atoms, mono- or di- (alkenyl of 2 to 6 carbon atoms) amino, alkyl of 1 to 6 carbon atoms (alkenyl of 3 to 6 carbon atoms) amino, alkenylcarbonylamino of 2 to 6 carbon atoms, alkenylcarbonyl of 2 to 6 carbon atoms (alkyl of 1 to 6 carbon atoms) amino, alkynyl of 2 at 6 carbon atoms, alkynyloxy of 3 to 6 carbon atoms, hydroxyalkynyl of 3 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms-alkynyl of 3 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms -alkynyloxy of 4 to 6 carbon atoms, alkynylcarbonyl of 2 to 6 carbon atoms, t ioalkynyl of 2 to 6 carbon atoms, alkylsulfonyl of 2 to 6 carbon atoms, alkylsulfonyl of 2 to 6 carbon atoms, mono or di- (alkynyl of 3 to 6 carbon atoms) amino, alkyl of 1 to 6 atoms of carbon (alkynyl of 3 to 6 carbon atoms) amino, alkynylcarbonylamino of 2 to 6 carbon atoms, or by alkynylcarbonyl of 2 to 6 carbon atoms (alkyl of 1 to 6 carbon atoms) amino; and / or the phenyl ring, the naphthyl ring system, and the 5- or 6-membered aromatic ring, may be substituted by alkyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, hydroxyalkyl of 1 at 6 carbon atoms, alkoxy of 1 to 6 carbon atoms-alkyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms-alkoxy of 1 to 6 carbon atoms, alkylcarbonyl of 1 to 6 carbon atoms , thioalkyl of 1 to 6 carbon atoms, alkylsulfinyl of 1 to 6 carbon atoms, alkylsufonyl of 1 to 6 carbon atoms, monoalkylamino of 1 to 6 carbon atoms, di (alkyl of 1 to 6 carbon atoms) amino, alkylcarbonylamino of 1 to 6 carbon atoms, alkylcarbonyl of 1 to 6 carbon atoms (alkyl of 1 to 6 carbon atoms) amino, alkenyl of 2 to 6 carbon atoms, alkenyloxy of 3 to 6 carbon atoms, hydroxyalkenyl of 3 at 6 carbon atoms, alkoxy of 1 to 6 carbon-alkenyl atoms of 2 to 6 carbon atoms or, alkoxy of 1 to 6 carbon atoms-alkenyloxy of 3 to 6 carbon atoms, alkenylcarbonyl of 2 to 6 carbon atoms, thioalkenyl of 2 to 6 carbon atoms, alkenylsulfinyl of 2 to 6 carbon atoms, alkenylsulfonyl of 2 at 6 carbon atoms, mono- or di- (alkenyl of 2 to 6 carbon atoms) amino, alkyl of 1 to 6 carbon atoms (alkenyl of 3 to 6 carbon atoms) amino, alkenylcarbonylamino of 2 to 6 atoms of carbon, alkenylcarbonyl of 2 to 6 carbon atoms (alkyl of 1 to 6 carbon atoms) amino, alkynyl of 2 to 6 carbon atoms, alkynyloxy of 3 to 6 carbon atoms, hydroxyalkynyl of 3 to 6 carbon atoms, alkoxy from 1 to 6 carbon-alkynyl atoms of 3 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms-alkynyloxy of 4 to 6 carbon atoms, alkynylcarbonyl of 2 to 6 carbon atoms; thioalkynyl of 2 to 6 carbon atoms, alkylsulfinyl of 2 to 6 carbon atoms, alkylsulfonyl of 2 to 6 carbon atoms, mono- or di (alkynyl of 3 to 6 carbon atoms) amino, alkyl of 1 to 6 atoms of carbon (alkynyl of 3 to 6 carbon atoms) amino, alkynylcarbonylamino of 2 to 6 carbon atoms or by alkynylcarbonyl of 2 to 6 carbon atoms (alkyl of 1 to 6 carbon atoms) amino, substituted by halogen; and / or the phenyl ring, the naphthyl ring system, and the 5- to 6-membered aromatic ring may be substituted by a radical of the formula COOR50, CONR51, SO2NR53R54, or SO2OR55, wherein R50, R51, R52, R53, R54, R55 are each independently of the others, alkyl of 1 to 6 carbon atoms, alkenyl of 2 to 6 carbon atoms, or alkynyl of 3 to 6 carbon atoms, substituted by halogen, hydroxyl, alkoxy, mercapto , amino, cyano, nitro, thioalkyl, alkylsulfinyl, or alkylsulfonyl; n is 0, 1 or 2; and R4, R5 and G are each as defined in claim 1, whose process comprises reacting a compound of the formula (2) wherein R0, R1, R2, R3 and n are as defined hereinbefore; R6 is R8R9N-; R7 is R10R11N- or R12O-; and R8, R9, R10, R11 and R12 are each indepe |
| priorityDate | 1999-06-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 38.