http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-026300-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_44367c7b17bf07d2d403f117a3fe1a97 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D261-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-444 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-82 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-80 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4425 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D- http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-87 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D263-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D261-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4436 |
| filingDate | 2000-10-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2003-02-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-026300-A1 |
| titleOfInvention | NEW COMPOUNDS FOR THE TREATMENT OF VASCULAR COMPLICATIONS RELATED TO DIABETES AND AGING, THE PROCESS FOR PREPARATION AND THERAPEUTIC USES. |
| abstract | It describes new compounds of the pyridinium series useful for the treatment of vascular complications due to diabetes and related to aging, including diseases of the kidney in nerves, atherosclerosis, retinopathies, dermatological disorders and discoloration of teeth, larupture of pre-formed AGE, of the general formula 1, or its pharmaceutically acceptable salts, wherein R1 is -R4-R5 or -N (R7) N (R7) R9; R4 is selected from the group formed by -N (R7) R6O-, -N (R7) R6N (R7) -, OR6O, and -OR6N (R7) -, where R6 is alkyl; R5 is selected from the group consisting of alkyl, aryl including heteroaryl, -COR7, SO2 R7; -C (S) NHR7, -C (NH) MHR7, -COR10, -C (O) NHR7 and -N (R7) N = CR7R10 where R7 is selected from the group consisting of H, alkyl and aryl including heteroarylsi R7 is different for R1 and R3 in the same compound; R2 is selected from the group consisting of H, alkyl and ryl including heteroaryl if R7 is different for R1 and R3 in the same compound; R2 is selected from the group consisting of F, CL, Br, I, OR7, NO2, alkyl, a ryl including heteroaryl, formyl, acyl, C (O) NR7R10, C (I) OR7, NR7R10, N = C (R7 ) (R10), SR7, SO2NH2, SO2 alkyl and SO2 aryl, and m is 0, 1 or 2; R3 is selected from the group consisting of R7, OR7, N (R7) (R10), N = C (R7) (R10), N (R7) N (R7) (R10), N (R7) N = C (R7 ) (R10) and CH (R7) C (O) R8 where R8 is selected from the group consisting of R7, OR7 and NR7R10; R9 is selected from the group consisting of hydrogen, alkyl, a ryl including heteroaryl, C (O) R10, -SO2R10, -C (S) NHR10, -C (NH) NH (R 10) and -C (O) NHR10, R10 it is selected from the group formed by H, alkyl or aryl including heteroaryl and in each case, is optionally different from the substituent R10, if R10 is different from R1 and R3 in the same compound; X is selected from the group formed by a halide, acetate, perchlorate, sulfonate, oxalate, citrate, tosylate, aminate, mesylate, carbonate, sulphite, phosphoric hydrogen, phosphonate, phosphate, BF4- and PF6 ion; with the proviso that, (i) when two alkyl groups are present in the same carbon or nitrogen, they are optionally linked to form a cyclic structure and (ii) the nitrogen of the heteroaryl ring of R10, when present, |
| priorityDate | 1996-02-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 54.