http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-024671-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_eccd894c99fea2d1c0c8735872bb2309 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D307-79 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D307-85 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B61-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-343 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-80 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-79 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-536 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-497 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-85 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-496 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4178 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4025 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-502 |
| filingDate | 2000-07-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2002-10-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-024671-A1 |
| titleOfInvention | DERIVATIVES OF BENZOFURAN, A PROCEDURE FOR THEIR PREPARATION, AND THE USE OF THE SAME AS INTERMEDIATE PRODUCTS FOR THE SYNTHESIS OF MEDICINES |
| abstract | Benzofuran derivatives of formula (1) wherein R represents 1-piperazinyl, 4-R1piperazinyl or L, R represents 2-R2-5-R3-pyrrole-1-ylcarbonyl, 4-R4-piperazin-1-ylcarbonyl, N, N-di (tert-butoxycarbonyl) aminocarbonyl, -CH = C (R5R6), benzofuran-2-yl-C. ..C-, -C (Hal) 3, -CO-C (Hal) 3,1,4-dihydrobenzo [d] [1,2] oxazin-3-ylcarbonyl or 3,4-dihydrobenzo-1H-phthalazin- 2-ylcarbonyl, L represents Cl, Br, I or a free or functionally modified OH group in a reactive group, R1, R4 each independently represents, H, benzyl or other amino protecting group, R2, R3 each independently represents, H, or C1-6R5 alkyl, R6 each independently represent, C1-6 alkyl, Hal represents F, Cl, Br or I, and the salts of these compounds. A procedure to prepare the benzofuran derivatives of formula (1) in which a) to prepare compounds of formula (1) in which R represents Cl, Br, I, 1-piperazinyl or 4-R1-piperazinyl, and R represents 2-R2-5-R3-pyrrol-1-ylcarbonyl, 4-R4-pip erazin-1-ylcarbonyl, 1,4-dihydrobenzo [d] [1,2] -oxazin-3-ylcarbonyl or 3,4-dihydrobenzo -1H-phthalazin-2-ylcarbonyl, a compound of formula (2) is reacted wherein R represents Cl, Br, I, 1-piperazinyl or 4-R1-piperazinyl and Q represents Cl, Br, I or a free OH group or functionally modified in a reactive group, and R1 has the meaning indicated in claim 1, with a compound of formula RH wherein R represents 2-R2-5-R3-pyrrol-1-yl, 4-R4-piperazin-1- ilo, 1,4-dihydrobenzo [d] [1,2] - oxazin-3-yl or 3,4-dihydrobenzo-1H-phthalazin-2-yl, and R2, R3 and R4 have the meanings indicated in claim 1 , ob) to prepare compounds of formula (1), in which R represents Cl, Br, I, 1-piperazinyl or 4-R1-piperazini lo, and R represents -CH = C (R5R6), benzofuran-2-yl-C ... C, -C (Hal) 3 or -CO-C (Hal) 3, and R1, R5 and R6 have the indicated meanings in claim 1, i) a compound of the formula (3) wherein Rrepresenta Cl, Br, I, 1-piperazinyl or 4- R1-piperazinyl is reacted with a compound of formula: Q-CH2-CO-R in where R represents -CH = C (R5R6), benzofuran-2-yl-C ... C-, -C (Hal) 3 or -CO-C (Hal) 3, and |
| priorityDate | 1999-07-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 32.