http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-024549-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_24e76490bed88751680a5fef9bc73892 |
| filingDate | 2000-05-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2002-10-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-024549-A1 |
| titleOfInvention | USE OF PROGESTERONE MODULATORS OF THE PROGESTERONE RECEPTOR AND PHARMACEUTICAL KIT FOR CYCLE REGIMES |
| abstract | This invention relates to therapies and cyclic combination regimens using substituted indoline-derived compounds that are progesterone receptor antagonists that have the general structure (1) in which R1 and R2 may be single or fused substituents to form spirocyclic or hetero-spirocyclic rings; R3 is H, OH, NH2, C1-6 alkyl, substituted C1-6 alkyl, C3-6 alkenyl, substituted C1-6 alkenyl, alkynyl, substituted alkynyl, CORc; Rc is H, C1-3 alkyl, substituted C1-aC3 alkyl, aryl, substituted aryl, C1-3 alkoxy, substituted C1-3 alkoxy, C1-3 aminoalkyl or substituted C1-3 aminoalkyl; R4 is H, halogen, CN, NO2, C1-6 alkyl, substituted C1-6 alkyl, alkynyl or substituted alkynyl, C1-6 alkoxy, substituted C1-6 alkoxy, amino amino C1-6 alkyl or substituted C1-6 aminoalkyl; and R5 is selected from a trisubstituted benzene ring of a ring of five or semi-members with 1,2 or 3 heteroatoms of the group includes O, S, SO, SO2 or NR6 and containing one or two independent substituents of the group including H, halogen, CN, NO2, amino and C1-3 alkyl C1-3 alkoxy, C1-3 aminoalkyl, COR (F) or NRGCORF; or its pharmaceutically acceptable salt. These treatment methods can be used for contraception or for the treatment and / or prevention of secondary amenorrhea, dysfunctional bleeding, uterine leiomyomata, endometriosis; polycystic ovary syndrome, carcinomas and edenocarcinomas of the endometrium, ovary, breast, colon, prostate or laminimization of side effects or cyclic menstrual bleeding. Additional uses of the invention include stimulation of food intake. Also provided are pharmaceutical compositions containing progesterone, Formula (1) receptor antagonist and / or salts thereof, as well as the uses for these compounds and compounds. |
| priorityDate | 1999-05-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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