| abstract |
The present invention relates to novel ABC1 polypeptides and nucleic acid molecules that encode them. The invention provides recombinant vectors, host cells and pharmaceutical compositions comprising the polynucleotides of ABC 1, as well as methods for producing ABC1 polypeptides. The invention also provides methods for the diagnosis, treatment, improvement and / or prevention of diseases associated with a disease. outflow of decreased cholesterol and / or low HDL cholesterol. The present invention also provides methods to identify compounds that modulate the expression of ABC1 and methods to detect the level of polypeptides and polynucleotides of ABC1 in a mammalian subject. The present invention also provides appropriate equipment and compositions to analyze the compounds to determine the activity that modulates the expression of ABC1 of the compound, as well as the appropriate equipment and compositions to determine whether the compound modulates the outflow of cholesterol that depends on ABC1. |