| abstract |
It refers to tricyclic Delta3-piperidine derivatives as alpha2 antagonists of the formula (1); N-oxide forms, pharmaceutically acceptable addition salts and stereochemically isomeric standards thereof, where Alk is C1-6 dialkane di; n is 1 or 2; X1 is -O-, -S-, -S (= O) or S (= O) 2-, each R1 independently hydrogen, halogen, C1-6 alkyl, nitro, hydroxy or C1-4 alkyloxy; D is a heterocycle containing mono, bio tricyclic nitrogen, a 2H-benzopyranone, a ben zamide, a benzophenone or a phenoxyphenyl with antagonistic activity the central alpha2 adrenoceptor. It also relates to its process for its preparation, pharmaceutical compositions and the use thereof for the preparation of a medication. |