http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-023260-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_287114022fd18ac32942a7d58b0ea658 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02A50-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-0821 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-06139 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-0802 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-078 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7052 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-43 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-46 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P1-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-21 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-13 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-05 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-097 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-12 |
| filingDate | 2000-04-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2002-09-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-023260-A1 |
| titleOfInvention | ACTIVE MACROCICLIC PEPTIDES AGAINST THE HEPATITIS C VIRUS. |
| abstract | It covers macrocyclic compounds of formula (1) active in vitro and in cellular assays against the NS3 protease of the hepatitis C virus, in which W is CH or N; R21 is H, halo, C1-6 alkyl, cycloalkyl, haloalkyl, C1-6 alkoxy, cycloalkoxy, hydroxy or N (R23) 2, wherein each R23 is independently H, C1-6 alkyl, or cycloalkoxy; and R22 is H, halo, C 1-6 alkyl, C 3-6 cycloalkyl, C 1-6 haloalkyl, C 1-6 thioalkyl, C 1-6 alkoxy, C 3-6 cycloalkoxy, C 2-7 alkoxy, C 3-6 cycloalkyl, C 6 aryl or C10 or Het, wherein Het is a 5, 6 or 7 membered heterocycle, saturated or not, containing 1 to 4 heteroatoms selected from nitrogen, oxygen and sulfur, said cycloalkyl, aryl or Het being substituted with R24, wherein R24 is H, C1-6 alkyl, C3-6 cycloalkyl, C1-6 alkoxy, C3-6 cycloalkoxy, NO2, N (R25) 2; NH-C (O) -R25 or NH-C (O) -NH-R25, wherein each R25 is independently H, C1-6 alkyl or C3-6 cycloalkyl; or R24 is NH-C (O) -OR26, wherein R26 is C1-6 alkyl or C3-6 alkylcycloalkyl; R3 is hydroxy, NH2, or a group of the formula -NH-R31, wherein R31 is arylC6 or C10, heteroaryl, -C (O) -R32, -C (O) -OR32, or -C (O) -NHR32 , wherein R32 is C1-6 alkyl or C3-6 cycloalkyl; D is an alkylene chain of 5 to 10 atoms, saturated or not, optionally containing 1 to 3 heteroatoms independently selected from O, S or N-R41, wherein R41 is H, C1-6 alkyl, cycloalkyl, or -C ( O) -R42 wherein R42 is C1-6 alkyl, C6 or C10 cycloalkyl or aryl; R 4 is H or 1 to 3 substituents on any carbon atom of said chain D, said substituent being independently selected from the group consisting of C 1-6 alkyl, C 1-6 haloalkyl, C 1-6 alkoxy, hydroxy, halo, amino, oxo , thio or C1-6 thioalkyl and A is an amide of formula -C (O) -NH-R5 where R5 is selected from the group consisting of C1-8 alkyl, C3-6 cycloalkyl, C6o C10 aryl or C7- aralkyl 16; or A is a carboxylic acid or a pharmacologically acceptable salt or ester thereof. |
| priorityDate | 1999-04-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 50.