| abstract |
3-Substituted 4-arylquinolin-2-one derivatives are disclosed, having the general formula (1) in which R and R1 are each, independently, hydrogen or methyl, R2, R3 and R4, are each , independently, hydrogen, halogen, nitroo trifluoromethyl, with the proviso that R2, R3 and R4 do not all contain hydrogen; R5 is bromine, chlorine or nitro; R6 is hydrogen or fluoro; n is an integer from 0 to 6; m is an integer equal to 0 or 1; and R7 is CH3, -CRR1OH, -CHO, -C = NOH, -COCH3 oaryl or optionally substituted by one or two substituents selected from the group consisting of halogen, hydroxy, methoxy, amino, acetylamino and trifluoromethyl; or a pharmaceutically acceptable, non-toxic salt thereof. Said compounds are modulators of the K + channels activated by calcium, of great conductance, and are useful in the treatment of disorders that are sensitive to the opening of the potassium channels. The pharmaceutical compositions containing said compounds are also described. |