| abstract |
The benzotiepine derivative responds to formula (I) where: q is an integer from 1 to 4; n is an integer from 0 to 2; R1 and R2 are independently selected from the group consisting of H, alkyl, alkenyl, alkynyl, haloalkyl, alkylaryl, arylalkyl, alkoxy, alkoxyalkyl, dialkylamino, alkylthio, (polyalkyl) aryl, and cycloalkyl, where alkyl, alkenyl, alkynyl, haloalkyl, alkylaryl , arylalkyl, alkoxy, alkoxyalkyl, dialkylamino, alkylthio, (polyalkyl) aryl, and cycloalkyl is optionally substituted with one or more substituents selected from the group consisting of OR9, NR9R10, N + R9R10RwA-, SR9, S + R9R10A-, P + R9R10R11A -, S (O) R9, SO2R9, SO3R9, CO2R9, CN, halogen, oxo, and CONR9R10, where the alkyl, alkenyl, alkynyl, alkylaryl, alkoxy, alkoxyalkyl, (polyalkyl) aryl, and cycloalkyl optionally possess one or more carbons substituted by O, NR9, n + R9R10A-, S, SO, SO2, S + R9A-, P + R9R10A-, or phenylene, where R9, R10, and Rw are independently selected from the group consisting of H, alkyl, alkenyl, alkynyl, cycloalkyl, aryl, acyl, heterocycle, ammonium alkyl, arylalkyl, carb oxyalkyl, carboxyheteroaryl, carboxyheterocycle, carboalkoxyalkyl, carboxyalkylamino, heteroarylalkyl, heterocyclylalkyl and alkylammonium alkyl; or R1 and R2 taken together with the C to which they are attached, form C3-10 cycloalkyl; R3 and R4 are independently selected from the group consisting of H, alkyl, alkenyl, alkynyl, acyloxy, aryl, heterocycle, OR9, NR9R10, SR9, S (O) R9, SO2R9 and SO3R9, where R9 and R10 are as defined above; or R3 and R4 together, form = O, = NOR11, = S, = NNR11R12, = NR9, or = CR11R12, where R11 and R12 are independently selected from the group consisting of H, alkyl, alkenyl, alkynyl, aryl, arylalkyl, alkenyl alkyl, alkylalkyl, heterocycle, carboxyalkyl, carboalkoxyalkyl or, cycloalkyl, cyanoalkyl, OR9, NR9R10, SR9, S (O) R9, SO2R9, SO3R9, CO2R9, CN, halogen, oxo and CONR9R10, where R9 and R10 are as previously defined, provided both R3 and R4 are not OH, NH2 and SH, or R11 and R12 together with the nitrogen atom or C to which they are attached, form a ring |