http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-019852-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_22bb35e7506d75111a66349b26a36db7 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P5-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-62 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-19 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-15 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P5-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-17 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-62 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-21 |
| filingDate | 1999-06-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2002-03-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-019852-A1 |
| titleOfInvention | INSULIN ANALOGS, PROCEDURE FOR PREPARATION, PRECURSOR OF INSULIN ANALOGS, DNA SEQUENCE CODING THEM, VEHICLE OF FUNCTIONAL EXPRESSION IN BACTERIA AND YEAST, GUEST CELL, PHARMACEUTICAL COMPOSITION, INJECTABLE INJECTATION OF INJECTION |
| abstract | Insulin analogs, or physiologically acceptable salt thereof, comprising the following formula (1) in which (A1-A5) represents the amino acid radicals in Positions A1 to A5 of Chain A of human insulin or animal insulin; (A15-A19) represents the amino acid radicals in Positions A15 to A19 of the human insulin or animal insulin A chain; (B8-B18) represents the amino acid radicals in Positions B8 to B18 of the human insulin or insulin insulin B chain; (B20-B29) represents the amino acid radicals in Positions B20 to B29 of the human insulin or animal insulin B chain; R8 represents Thr or Ala, R9 represents Ser or Gly, R10 represents Ile or Val, R14 represents Tyr, His, Asp or Glu, R21 represents Asn, Asp, Gly, Ser Thr, Ala, Glu or Gln, R1 represents amino acid radical arbitrarily genetically encodable, absent or a hydrogen atom, R2 represents Val, Ala or Gly, R3 represents Asn, His, Glu or Asp, R4 represents Ala, Ser, Thr, Asn, Asp, Gln, Gly or Glu, R30 represents a radical genetically encodable arbitrary amino acid, or SYMBOL 45 \ FSymbol \ S 120H, Z represents a hydrogen atom or a peptide radical with 1 to 4 genetically encodable amino acid radicals, containing 1 to 4 histidine radicals (His), with the condition that, in the case in which Z represents an atom of H, R1 or R3 represents His, Glu, or Asp, and R3 = His, when R1 represents an amino acid radical with a neutral or relatively negative charge, or with the condition that, for the case in which Z represents a hydrogen atom, R14 represents His, Asp or Glu, and also s with the condition that the insulin analogue or the salphysiologically acceptable of the same of the formula (1) is not differentiated only by the variation of the amino acid radicals in the R3 or R3 positions linked to R21 or R3 bound with R4 in the formula (1) of human insulin These insulin analogues have a greater ability to bond with zinc, and zinc complexes of the same, and in comparison with human insulin have a delayed activity profile. Procedure for its preparation, |
| priorityDate | 1998-06-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 126.