http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-019178-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2ca2e4410855da087e11bf3eea8933fa |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P41-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-14 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4545 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4427 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4433 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-443 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-444 |
| filingDate | 1999-06-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2001-12-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-019178-A1 |
| titleOfInvention | COMPOUNDS OF 7- (BENZO (B) THIOPHEN, FURAN AND INDOLPIRIDIL OR TETRAHYDROPIRIDIL), EFFECTS ON SYSTEMS RELATED TO SEROTONINE, PHARMACEUTICAL COMPOSITIONS FORMULATED WITH SUCH COMPOUNDS; INTERMEDIARY COMPOUNDS USEFUL TO PREPARE SUCH THIOPHEN, FURAN AND INDOLPIRIDILE COMPOUNDS OTETR |
| abstract | These are compounds of formula I, useful for inhibiting the absorption of serotonin, antagonizing the 5-HT1a receptor and antagonizing the 5-HT2a receptor, by administering persons who refer to said treatment, characterized in that effective amounts of a compound of formula I where X is O, S, NR, S (= O) or S (= O) 2; Y is -C (= O) -, -CH (OH) -, CH2, -C (= NOR), CHNR7R, S, SO or SO2; = represents a single or double bond; n is 1, 2, 3 or 4; R is H or C1-6 alkyl; each of R1a, R1b, R1c and R2 is, independently, H, F, Cl, Br, I, OH, C1-6 alkyl, C1-6 alkoxy, halo- C1-6 alkyl, C1-6 alkylthio, phenyl , NO2, -NR7R8, -C (= O) NR78R8, -NR7C (= O) R8, CN or phenyl substituted with 1 to 3 substituents selected from the group consisting of F, Cl, B r, I, OH, C1-6 alkyl , C1-6 alkoxy, halo- C1-6 alkyl, C1-6 alkylthio, phenyl, NO2, NH2 or CN; R3 is H, OH, hydroxy-C1-6 alkyl, C1-6 alkyl, C1-6 alkoxy or C1-6 alkylthio; R4 esaryl, heterocycle, C3-8 cycloalkyl, aryl substituted with 1 to 3 substituents s selected from the compound group by F, Cl, Br, I, OH, C 1-6 alkyl, C 1-6 alkoxy, C 1-6 haloalkyl, C 1-6 alkylthio, phenyl, NO 2, NH 2 or CN; or heterocycle substituted with 1 to 3 substituents selected from the group consisting of F, Cl, Br, I, OH, C1-6 alkyl, C1-6 alkoxy, halo- C1-6 alkyl, C1-6 alkylthio, phenyl, NO2, NH2 or CN; R5 is aryl, heterocycle, C3-6 cycloalkyl, arylsubstituted with 1 to 3 substituents selected from the group consisting of F, Cl, Br, I, OH, C1-6 alkyl, to C1-6 lkoxy, hydroxy-C1-6 alkyl , halo- C1-6 alkyl, phenyl, NO2, NH2 or CN; or heterocycle substituted with 1 to 3 substituents selected from the group consisting of F, Cl, Br, I, OH, C 1-6 alkyl, C 1-6 alkoxy, C 1-6 hydroxy-alkyl, C 1-6 alkylthio, phenyl, NO 2 or CN ; each of R6a and R6b is, independently, H or C1-3 alkyl; each of R7 and R8 is independently, H, C1-6 alkyl, aryl or aryl substituted with 1 to 3 substituents selected from the group consisting of F, Cl, Br, I, OH, C1-C6 alkyl, C1-6 alkoxy, halo -C 1-6 alkyl, C 1-6 alkylthio, phenyl, NO 2, NH 2 or CN; and pharmaceutically salts thereof. They are also proposed |
| priorityDate | 1998-06-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 52.