http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-018170-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_966a6c1f382ec9bcb5e3839dfd73e5b8 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C49-83 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C69-712 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C59-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D257-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C49-835 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C59-90 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C45-74 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C45-62 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-19 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C45-74 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C235-76 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D257-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C69-712 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C45-62 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C59-90 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C49-835 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-192 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C49-83 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-41 |
| filingDate | 1999-03-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2001-10-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-018170-A1 |
| titleOfInvention | USE OF PHENOXYACETIC ACID AND TETRAZOL PHENOXYMETIC ACID DERIVED WITH ANTITUMORAL ACTIVITY, COMPOUNDS AND PHARMACEUTICAL COMPOSITION THAT UNDERSTANDS THEM. |
| abstract | Use of phenoxyacetic acid and phenoxymethyl tetrazole derivatives comprising formula (I), in which: the group -O-C (R1) (R2) - (CH2) p-A can be found in ortho, meta or para position; A is selected from -COOH, -COO-C1-4 alkyl, -CN or a group deforming u (II), in which R is hydrogen or C1-4 alkyl; or the group A- (CH2) p-C (R1) (R2) - is selected from phenyl, benzyl or (indolyl) methyl, which may be substituted with R4 groups; p is 0, 1 or 2; R1 and R2 are independently selected from hydrogen C1-8 alkyl or form, together with the carbon atom with which they are attached, a C3-7 cycloalkyl group; R4 is 0 to 2 substituents independently selected from chlorine, bromine, iodine, fluorine, linear or branched groups C1-8 alkyl, hydroxy, iC1-4 alkoxy, C1-4 acyl; or the group (III) in the formula (I) is a naphthyl group that can be substituted with R4 groups; n is an integer from 1 to 4; month 0 or 1; B is selected from the linear or branched group C1-10 alkyl, -CO-C (R3) = CH-R, -CH = C (R3) -CO -Ar, -CO-CH (R3) -CH2-R or - CO-CH (R3) -CH2-NR5R6 is 0, or is -CH = C (R3) -CO-Ar when m is 1; R is selected from hydrogen, -Ar or -CO-Ar; R3 is hydrogen or a C1-8 alkyl group; R5 and R6 are independently a C1-4alkyl group, or together with the nitrogen atom with which they are attached, a piperidino, piperazino, C1-8 alkylpiperazino, morpholino or thiomorpholino group; Ar is a phenyl group which may be unsubstituted or substituted with 1 to 3 independently selected groups of chlorine, bromine, iodine, fluorine, linear or branched groups C1-8 alkyl, hydroxy, C1-4 alkoxy, C1-4 acyl, stereoisomers of the same salts thereof with pharmaceutically acceptable acids or bases for the preparation of a medicament that has MDM2 antagonistic activity. Derivatives of formula (I) with the proviso that when A is selected from -COO-C1-4 alkyl, -CN or a group of formula (II) in which R is hydrogen or C1-4 alkyl; and when m is 0 and A is a -COO-C1-4 alkyl group, B can only be a group of formula -CO-CH (R3) -CH2-NR5R6 and pharmaceutical composition that |
| priorityDate | 1998-03-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 58.