| abstract |
The present invention relates to a compound of the formula (1), in which R2 is a lower alkyl group optionally substituted by hydroxy, amino and the like, ring B is phenyl, thienyl and the like; E is a simple bond, -O-, -S- and the like, the G ring is an aryl, heterocyclic group and the like; R5 is a halogen atom, a hydroxy group, lower alkyl optionally substituted by a halogen atom, etc .; and similar; t is 0 or an integer that ranges from 1-5, while when it is an integer that ranges from 2 to 5, each R5 can be the same or different; m is 0 or unentero ranging from 1 to 8; and n is 0 or an integer ranging from 1 to 4; and to a nocicpetin antagonist that contains compound (1) as an active ingredient. The compound (1) demonstrates, due to its antagonistic action of nociceptin, analgesic effect against acute pain such as post-operative pain and the like. The present invention also relates to the use of a certain amide derivative comprising the compounds (1) as a nociceptin antagonist or analgesic. |