http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-017230-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_14effe3850d2129f863b969dac4f1db8 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D407-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D249-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D333-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D231-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D233-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D307-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D243-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D243-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P19-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P19-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D521-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-5513 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-551 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-10 |
| filingDate | 1999-01-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2001-08-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-017230-A1 |
| titleOfInvention | ACIDS 2, 3, 4, 5-TETRAHYDRO. 1H. [1,4] -BENZODIAZEPINA-3-HYDROXAMICS AND PHARMACEUTICAL COMPOSITION CONTAINING THEM AND USE OF SUCH COMPOUNDS TO PREPARE A MEDICINAL PRODUCT. |
| abstract | 2,3,4,5-tetrahydro.1H [1,4] -benzodiazepine-3-hydroxamic acids comprising the formula I in which R is selected from hydrogen, (C1-3) alkyl - CN, OR, -SR, -CF3, OCF3, Cl, F, NH2, NH C1-3 alkyl, -N (R) CO C1-3 alkyl, -N (R) (R), NO2, -CONH2, -SO2NH2- -SO2N (R) (R), or -N (R) COCH2O-C1-3 alkyl, where R is C1-3 alkyl or hydrogen, R4 is C1-6-o- alkyl, C1-6-S-II alkyl, in which R is hydrogen, cyano, methyl or -OCH3, R1 and R2 are each independently hydrogen or CH3, R3 is C1-8 alkyl, NH2CH2CO-, C1-6 alkyl NHCH2CO-, HO (CH2) mCO-, HCO-, aryl (CH2) nCO-, heteroaryl (CH2) nCO-, C1-3-O- (CH2) nCO- alkyl, C1-3 CO- alkyl, C1-3 CO-NHCH2CO- alkyl, C3-7 CO- cycloalkyl, C1-3 alkyl SO2-, aryl (CH2) n SO2-, heteroaryl (CH2) n SO2-, C1-3-O- (CH2) m-SO2- alkyl, C1-3-O- (CH2) m alkyl, C1-3 alkyl) -O- (C1-3 alkyl) -O- (C1-3 alkyl), HO-C1-3 alkyl-O-C1-3 alkyl, aryl-O-CH2CO- heteroaryl-O-CH2- CO-, arylCH = CHCO, heteroarylCH = CHCO, C1-3 alkyl CH = CHCO, III; Aryl C1-3 alkyl, heteroaryl C1-3 alkyl, arylCH = CHCH2-, heteroarylCH = CHCH2-, C1-6 alkyl CH = CHCH2-, IV; ROCH2CH (OR) CO-, (ROCH2) 2C (R) CO-V; [C1-6 alkyl] 2-N-C1-6 alkyl CO-, or C1-6 alkyl-NH-C1-6 alkyl-; where m = 1 to 3; n = 0 to 3; aryl esVI and heteroaryl is VII where X eas hydrogen, halogen, C1-3 alkyl or -OCH3 and R and R are as defined above; L is hydrogen, C1-3 alkyl, -CN, -OR, -SR, -CF3, -OCF3, Cl, F, NH2, -NH-, C1-3 alkyl, -N (R) CO C1-3 alkyl, N (R) (R), -NO2, -CONH2, -SO2NH2, -SO2N (R) (R), -N (R) COCH2O-C1-3 alkyl, VIII, M is IX or N (R) (R) where R is as defined above; W is O, S, NH or N C1-3 alkyl; Y is hydrogen, F, Cl, CF3 or OCH3 and X is halogen, hydrogen, C1-3 alkyl, O-C1-3 alkyl or -CH2OH; and pharmaceutically acceptable substrates, pharmaceutical composition containing them and use of said compounds to prepare a useful drug for the treatment of conditions of disorders mediated by the metalloproteinase matrix. |
| priorityDate | 1998-01-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 44.