| abstract |
A process for preparing naphthyridones of formula I is described, R 1 is benzyl, where the benzyl phenyl may be substituted by one or more of C 1-6 alkyl, C 1-6 alkoxy, halogen, nitro, amino or trifluoromethyl, and R 2 is C 1 alkyl -6, trifluoromethyl or phenyl, which may be substituted by one or more C1-6 alkyl, halogen C1-6 alkoxy, nitro, amino or trifluoromethyl, which comprises (a) reducing a compound of formula II in which R1 is as it has been defined above, iron presence and an organic solvent under acidic conditions, and (b) acylating the compound of formula III formed with an agent of formula R2C (O) X, where R2 is as defined. Methods for preparing synthesis intermediaries are also described. The compounds preparation procedure were described useful for the treatment of bacterial diseases |