| abstract |
The present invention is directed to a new topical pharmaceutical composition of water in oil in the form of a cream or lotion, comprising (i) 2-50% of a local anesthetic in the form of oil in the final composition, or two or more anesthetics premises that form an oil when mixed, effective to produce a topical anesthetic effect with the administration; (ii) 2-50% of a water-in-oil emulsifier, effective to produce an emulsion of the desired viscosity; and (iii) 2-96% water. Optionally the composition may contain up to 20% of penetration enhancers or pharmaceutically acceptable stabilizers. This new pharmaceutical composition is useful in therapy, particularly for the treatment of pain. |