http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-016675-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1bde28565d28f037e78bf4a67776ee24 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-343 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D307-87 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C69-76 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C255-53 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C235-42 |
| filingDate | 1998-11-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2001-07-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-016675-A1 |
| titleOfInvention | METHOD FOR THE PREPARATION OF CITALOPRAM AND ANTIDEPRESSIVE PHARMACEUTICAL COMPOSITIONS THAT INCLUDE PREPARED CITALOPRAM. |
| abstract | A method for the preparation of citalopram is described which comprises the reduction of the oxo group of a compound of formula IV where R 1 is CN or C 1-6 alkyloxycarbonyl or C 1-6 alkylaminocarbonyl, effecting the closure of rings of the hydroxyresulting compound, by which it is obtained The corresponding 1 (4-fluorphenyl) 1,3-dihydroisobenzofuran, then if R 1 is cyano, using it directly in the next step and if R 1 is C 1-6 alkyloxycarbonyl or C 1-6 alkylaminocarbonyl, the conversion of the compound into the corresponding compound where R 1 is cyano , and the alkylation of the 5-cyano compound resulted with 3-dimethyl-aminopropyl halide under basic conditions by which citalopram is obtained; and antidepressant pharmaceutical compositions that comprise citalopram manufactured by the method. |
| priorityDate | 1997-11-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 19.