| abstract |
Piperidine derivatives, which comprise compounds of the formula (I) where: X is -O- or -CH2-; Y is -C (O) -, - (CH2) n or -N (CH3); n is 1 or 2, or X and Y together are -CH = CH-; Z is -NH-, -CH2, -O- or = CH-; A1 is a group of formula (a) or (b); B is - (CH2) m; m is 0, 1 or 2; R1 and R2 are each independently linear or branched C1-6 hydrogen or alkyl; R3 is hydrogen or halogen; R4 is hydrogen or hydroxy and the dotted line is an optional -CH2-CH2 group and the pharmaceutically acceptable acidic salts thereof. The compounds are OFQ receptor antagonists. Consequently, they will be useful in the treatment of memory and attention, psychiatric, neurological and physiological disorders, especially, without this being limiting, in alleviating the symptoms of anxiety and stress disorders, depression, memory loss due to Alzheimer's disease or other dementias, epilepsy and seizures, acute and / or chronic states of pain, symptoms of addictive drug withdrawal, water balance control, arterial blood pressure disorders and Na + excretion and metabolic disorders , such as obesity. It also describes a process for its preparation, a medicine that comprises them and the use of the same piperidine derivatives for the manufacture of a medicine. |