| abstract |
Monocyclic benzamides of 3- (4-substituted) 4- (aminomethyl) -piperidine derivatives comprising compounds of formula (I), a stereochemically isomeric form thereof, an N-oxide form thereof or an addition salt of Acidically pharmaceutically acceptable acid thereof, R 1 is C 1-6 alkyloxy, C 2-6 alkenyloxy or C 2-6 alkynyloxy; R2 is hydrogen, C1-6 alkyl or C1-6 alkyloxy; R3 is hydrogen or halo; R4 is hydrogen or C1-6 alkyl; R5 is hydrogen C1-6alkyl; L C 3-6 cycloalkyl, C5-6 cycloalcanone or C2-6 alkenyl, or L is a radical of formula -Alk-R6-, -Alk-X-R7-, -Alk-YC (= O) -R9 or - Alk-YC (= O) -NR11R12 where Alk is C1-12 alkanediyl; R6 is hydrogen, cyano, C1-6 alkylsulfonylamino, C3-6 cycloalkyl, C5-6 cycloalcanone or a heterocyclic ring system group; R7 is hydrogen, C1-6 alkyl, C1-6 hydroxyalkyl, C3-6 cycloalkyl, or a heterocyclic ring system; X is O, S, SO2 or NR8; R8 being C1-6 alkyl hydrogen; R9 is hydrogen, C1-6 alkyl, C3-6 cycloalkyl, C1-6 alkyloxy or hydroxy; Y is NR10 or a direct bond, said R10 being hydrogen or C1-6 alkyl; R11 and R12 are each independently hydrogen, C1-6 alkyl, C3-6 cycloalkyl or R11 and R12 combined with the denitrogen atom bearing R1 1 and R12 can form a pyrperidinyl p piperidinyl ring and both can be optionally substituted with C1-6 alkyl , amino or mono or di (C1-6 alkyl) amino or said R11 and R12 combined with the nitrogen carrying R11 and R12 can form a piperacinyl or 4-morpholinyl radical being both optionally substituted with C1-6 alkyl; and Het1 and Het2 are each independently selected from furan; furan substituted with C1-6 alkyl ohalo, tetrahydrofuran; a tetrahydrofuran subst ituido with C1-6 alkyl; a dioxolane; a dioxolane substituted with C1-6 alkyl; a dioxane; a dioxane substituted with C1-6 alkyl; tetrahydropyran; a tetrahydropyran substituted with C1-6 alkyl; pyrrolidinyl; a pyrrolidinyl substituted with one or two substituents each independently selected from halo, hydroxy, cyano or C1-6 alkyl; pyridinyl; pyridinyl substituted with one or two substituents each |