| abstract |
Use of pharmaceutical compounds having an NMDA antagonistic activity to prepare a medicament, where especially suitable compounds have laformula (I) where R1 and R2 are independently phenyl or 4-fluosophenyl; R3 is hydrogen, C1-6 alkyl or methoxycarbonyl; R4 is hydrogen or methyl; and metabolites and their isomers both as free base and their pharmaceutically acceptable salts, useful for treating certain conditions in the gastrointestinal tract, such as functional gastrointestinal gastrointestinal disorders, and in particular, irritable bowel syndrome (IBS); Pharmaceutical compositions for use in the treatment of IBS comprising compounds and a pharmaceutically acceptable carrier. |