http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-016144-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2ca2e4410855da087e11bf3eea8933fa |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-07 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C215-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C213-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C211-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C319-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C323-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C215-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C319-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C59-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C217-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C213-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C213-06 |
| filingDate | 1998-10-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2001-06-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-016144-A1 |
| titleOfInvention | PROCEDURE FOR PREPARING S - (+) N-METHYL-3-R-HYDROXY-3-PHENYLPROPYLAMINE MANDELATE AND R - (-) - N-METHYL-3S-HYDROXY-3-PHENYLPROPYLAMINE MANDELATE AND LASSALES THEREOF; PROCESS TO PREPARE N-METHYL-3-R- (PHENOXISUSTITUTED) -3-PHENYLPROPYLAMINE, AS INTERMEDIARIES OF APPLICATION IN THIS PROCEDURE |
| abstract | It is the preparation of the S - (+) - Mandelic acid salt of N-methyl-3R-hydroxy-3-phenylpropylamine, which comprises reacting N-methyl-3 (R, S) -hydroxy-3 -phenylpropylamine and the R (-) - Mandelic acid salt of N-methyl-3S-hydroxyphenylpropylamine 3 (R, S) -hydroxy-3-phenylpropylamine with S - (+) mandelic acid respectively with R (-) acid -mandelic. The mentioned salts and processes for producing N-methyl-3R- (2-methylthiophenoxy) -3-phenylpropylamine and N-methyl-3R- (2-methylphenoxy) -3-phenylpropylamine are also described and claimed using the aforementioned enantiomeric salts and a procedure for the preparation of S-fluoxetine of formula (c) by reacting a) the salt R (-) (+) N-methyl-3-S-hydroxy-3-phenylpropylamine mandelate with a base (a) to form the compounds (formula a) and react this compound with 4-trifluoromethylhalobenzene: formula (b), where X is fluorine or chlorine. |
| priorityDate | 1997-10-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 38.