| abstract |
Compounds of substituted 1,2,4-triazol [4,3-b] pyrido [3,2-d] pyridazine; method of preparing said compounds, pharmaceutical compositions formulated with said compounds and using said compounds for the manufacture of medicaments without phosphodiesterase hybridizers 4. Heterocyclic compounds of formula (I), wherein R1 represents a hydrogen atom or a group - (CH2) mY wherein m is a number from 0 to 4 and Y represents an alkyl, haloalkyl, alkoxy, alkoxycarbonyl, C3-7 cycloalkyl, norbornyl or phenylalkyl group, or an aromatic group whose aromatic group Y is optionally substituted by one or more halogen atoms ; R2 represents an aromatic group, whose aromatic group is optionally substituted by one or more halogen atoms or alkyl, alkoxy, C-3-6 cycloalkoxy, methylenedioxy, nitro, dialkylamino or trifluoromethyl groups; and R3 represents a hydrogen atom or halogen or an alkyl group, and pharmaceutically acceptable salts thereof. The objects are also provided in the title of this application. |