| abstract |
Compounds derived from triazole that represent high affinity with the dopamine D3 receptor and lower affinity with D2, that is, selective D3 ligands, of the formula I wherein Ar1 corresponds to phenyl, naphthyl or a heterocyclic aromatic chain of 5 or 6 links with 1 to 4 heteroatoms independently selected from each other, between O, S and N, whereby, eventually, Ar1 has 1, 2, 3 or 4 substituents independently selected from each other between C1-6-alkyl which is eventually substituted by OH, OC1- 6-alkyl, halogen or phenyl, C1-6-alkoxy, C2-6-alkenyl, C2-6-alkynyl, C3-6-cycloalkyl, halogen, CN, COOR2, NR2R2, NO2, SO2NR2R2 and phenyl, which is eventually substituted by C1-6-alkyl, OC1-6-alkyl, NR2R2, CN, CF3, CHF2, or halogen and with which the heterocyclic aromatic chain mentioned, can eventually be condensed with a phenyl cycle, A corresponds to C4-10-alkylene oramified linear chain, which at least comprises a group Z, chosen from O, S, NR2, CONR2, COO, CO of a double or triple bond, B a remainder of the formula II or when Ar1 corresponds to a heterocyclic aromatic chain of 5 or 6 links that can be substituted as indicated, B can also correspond to a residue of the formulas III, Ar2 corresponds to phenyl, pyridyl, pyrimidyl or triazinyl, whereby, eventually, Ar2 may have one to four substituents independently selected from each other from OR2, C1-6-alkyl, C2-6-alkenyl, C2- 6-alkynyl, C1-6-alkoxy-C1-6-alkyl, halogen-C1-6-alkyl, halogen-C1-6-alkoxy, halogen, CN, NO2, SO2R2, NR2R2, SO2NR2R2, an aromatic or non-aromatic chain carbocyclic of 5 or 6 links, and a heterocyclic aromatic chain or one of heterocyclic 5 or 6 links with 1 or 2 heteroatoms, chosen between O, S and N, whereby, eventually, the heterocyclic carbocyclic chain can be substituted by C1-6- alkyl, phenyl, phenoxy, halogen, OC1-6-alkyl, OH, NO2 or CF3 and / or can be condensed with u A phenyl chain and whereby Ar2 may eventually be condensed with a carbocyclic, aromatic or non-aromatic chain and with an aromatic or non-aromatic heterocyclic chain |