http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-015637-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_12a135a933620c99beab01d4ac785d25 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7c9391dc4b6011e7e181a5f46f6d807b |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K41-0071 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K41-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-22 |
| filingDate | 1998-05-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2001-05-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-015637-A1 |
| titleOfInvention | A PHOTOACTIVE COMPOUND DERIVED FROM BENZOPORPHIRINE; A METHOD TO PREPARE SUCH COMPOUND; A PHARMACEUTICAL COMPOSITION THAT INCLUDES IT AND USE OF THE PHOTOACTIVE COMPOUND FOR THE PREPARATION OF A PHARMACEUTICAL COMPOSITION |
| abstract | A new photoactive compound derived from benzoporphyrin that extends the repertoire of compounds useful in the photodynamic therapy of formula1, 2, 3, 4 where R1 is alkyl (1-6C) is described; Y is -OH or -NR2 or -NHNR2, where each R2 is independently H or a substituted or unsubstituted hydrocarbon radical of 1-10C or where both R2 taken together provide a cyclic or multicyclic amine of 1-20C; or is -OR3 where R3 is (1-10C) alkyl substituted with at least one substituent containing heteroatoms; n is an integer of 0-6 each X is independently -OH or -OR4 where R4 is a substituted hydrocarbon radical of 1-10C; or is -NR2 (2) where R2 has the values defined above; or is -OR3 where R3 has the values defined above; and R5 esvinyl or a derivative thereof. Monohydrobenzoporphyrins can be obtained in the form of a triazide or as esters with substituted heteroatom alcohols or as amides. Photodynamic therapy (PDT) was initially developed in the treatment of tumors, since it seemed that the compounds would be housed in the points that contained rapidly dividing cells. Since then, PDT has proven to be useful in the treatment of atherosclerotic plaques, restenosis, blood infections, rheumatoid arthritis, psoriasis and in the treatment of eye conditions not necessarily limited to tumors. A method for preparing the compound comprises treating a more highly esterified form of said benzoporphyrin compound or salt, forms with incorporated or labeled metals or conjugated metals thereof with a base and solvent and a solvent for a time sufficient to result in deesterification and thus obtain The product compound. A pharmaceutical composition comprises the benzoporphyrin compound in admixture with at least one acceptable pharmaceutical excipient. An improved method for carrying out photodynamic therapy or making diagnosis comprises administering a photoactive compound to a subject that needs such therapy or diagnosis. |
| priorityDate | 1997-05-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 21.