| abstract |
A compound of the formula (I) or the pharmaceutically acceptable salt thereof; in which one of R1 and R2 is independently selected from the group consisting of hydrogen, C1-6 alkyl, C3-7 cycloalkyl, C6-10 aryl, C5-9 heteroaryl and C2-9 erocycloalkyl group, where the alkyl, cycloalkyl groups , aryl, heteroaryl or heterocycloalkyl are optionally substituted with halo, hydroxy, C1-6 alkyl, C1-6 alkoxy, amino, C1-6 alkylamino, (C1-6 alkyl) 2-amino, thio, C1-6 alkylthio, cyan or , carboxy, carboxy-C 1-6 alkyl, hydroxy-C 1-6 alkyl, C 1-6 acyl, aminosulfonyl, C 1-6 alkylaminosulfonyl or (C 1-6 alkyl) 2-aminosulfonyl; and R3 is hydrogen, halo, hydroxy, C1-6 alkyl, C1-6 alkoxy, amino, C1-6 alkylamino, (C1-6 alkyl) 2-amino, thio, C1-6 alkylthio, carboxy, carboxy-C1-6 alkyl , hydroxy-C1-6 alkyl, acyl C1-6, aminosulfonyl, alkylaminosulfonyl C1-6 or (C1-6 alkyl) 2-aminosulfonyl, useful in the treatment of respiratory, allergic, rheumatoid, body weight regulation, inflammatory and of the central nervous system, such as asthma, chronic obstructive pulmonary disease, adult respiratory disease syndrome, toxic shock, fibrosis, pulmonary hypersensitivity, rhinitisallergic, dermatit is atopic, psoriasis, weight control, rheumatoid arthritis, cachexia, Crohn's disease, colitis ulcerative, arthritic conditions and other inflammatory diseases, depression, multi-infarct dementia and AIDS. |