http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-014974-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_02d2b7b5831d88d46035d44c54256fb0 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-62 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-61 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D295-108 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P27-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D241-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-445 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-495 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4545 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-454 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-108 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4427 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-06 |
| filingDate | 1999-04-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2001-04-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-014974-A1 |
| titleOfInvention | COMPOUNDS WITH ACTIVITY ON MUSCARINIC RECEPTORS, A PHARMACEUTICAL COMPOSITION THAT INCLUDES THEM AND THE USE OF THEM FOR THE MANUFACTURE OF A MEDICINE |
| abstract | A compound with activity on muscarinic receptors, comprising formula (I) wherein: X1, X2, X3, X4 and X5 are selected from C, N and O; k is 0o 1; t is 0, 1 or 2; R1 is branched or straight chain C1-8 alkyl, C2-8 alkenyl, C1-8 alkynyl, C1-8 alkylidene, C1-8 alkoxy, C1-8 heteroalkyl, C1-8 aminoalkyl, C1-8 haloalkyl, C1-8 alkoxycarbonyl , C1-8 hydroxyalkoxy, C1-8 hydroxyalkyl, -SH, C1-8 alkylthio, -O-CH2-C5-6 aryl, -C (O) -C5-6 arylsubstituted with C1-3 alkyl or halo; C5-6 aryl or C5-6 cycloalkyl optionally comprising 1 or more heteroatoms selected from N, S and O; -C (O) NR3R4, -NR3R4, -NR3C (O) NR4R5, -CNR3R4, -OC (O) R3, - (O) (CH2) sNR3R4 or - (CH2) sNR3R4; where R3, R4 and R5 are the same or different; each is independently selected from H, C1-6 alkyl; C5-6 aryl which optionally comprises 1 or more heteroatoms selected from N, O and S, and optionally substituted with halo or C1-6 alkyl; C3-6 cycloalkyl; or R3 and R4 together with the N atom, when present, form a cyclic ring structure comprising 5-6 atoms selected from C, N, S and O; and s is an integer from 0 to 8; A is C5-12 aryl or C5-7 cycloalkyl; each optionally comprises 1 or more heteroatoms selected from N, S and O; R 2 is H, amino, hydroxyl, halo, or straight or branched C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 alkoxy, C 1-6 heteroalkyl, C 1-6 aminoalkyl, C 1-6 haloalkyl , C1-6 alkylthio, C1-6 alkoxycarbonyl, -CN, -CF3, -OR3, -COR3, NO2, -NHR3, -NHC (O) R3, -C (O) NR3R4, -NR3R4, -NR3C (O) NR4R5, -OC (O) R3, -C (O) R3R4, -O (CH2) qNR3, -CNR3R4 or - (CH2) qNR3R4; where q is an integer from 1 to 6; n is 0, 1, 2, 3, or 4, the groups R2, when> 1, are the same or different; p is 0 or an integer from 1 to 5; Y is O, S, CHOH, -NHC (O) -, -C (O) NH-, -C (O) -, -OC (O) -, NR7 or -CH = N-, and R7 is H or C1-4 alkyl; absent Z is CR8R9 wherein R8 and R9 are independently selected from H and straight or branched C1-8 alkyl; provided that when - (CH2) p-Y- is- (CH2) 3-C (O) - or - (CH2) 3-S-, and X1 to X5 are C; that -A- (R2) n and R1 are not together: o-methyl-phenyl and n-butyl, respectively; phenyl and n-butyl, respectively; |
| priorityDate | 1998-03-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 42.