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filingDate 1999-02-04-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 2001-02-28-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber AR-014539-A1
titleOfInvention DERIVATIVES OF 5'-DEOXICITIDINE, A PHARMACEUTICAL COMPOSITION AND KIT THAT UNDERSTANDS THEM, THE USE OF THE SAME FOR THE MANUFACTURE OF A MEDICINAL PRODUCT
abstract 5-Deoxycytidine derivatives comprising a compound represented by the general formula (I) in which R 1 is each independently hydrogen or an easily hydrolysable group under physiological conditions; R2 is - (CH2) n-cycloalkyl [wherein cycloalkyl contains 3 to 5 carbon atoms, n is an integer from 0 to 4], heteroaryl- (lower-alkyl), (lower-alkoxy) - (lower-alkyl) , aryloxy- (lower-alkyl), aralkyloxy- (lower-alkyl), (lower-alkyl) - (lower-alkyl), arylthio- (lower-alkyl), aralkylthio- (lower-alkyl), oxo- (alkyl- lower), acylamino- (lower-alkyl), cyclic amino- (lower-alkyl), (2-oxocyclic amino) - (lower-alkyl), wherein the alkylene chain may be further substituted with one or two lower-alkyl groups and R3 is iodine, a vinyl or ethynyl group, (said groups may be substituted with a halogen atom or atoms, C1-4 alkyl, cycloalkyl, aralkyl, or an aromatic ring that may have one or more heteroatoms], a pharmaceutical composition and kit that includes them, the use of them for the manufacture of an antitumor drug.
priorityDate 1998-02-06-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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