http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-014411-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_07b71571160c289fbf5fc680dfea513f |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-41 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D285-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-275 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4245 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D271-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D271-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-433 |
| filingDate | 1999-01-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2001-02-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-014411-A1 |
| titleOfInvention | THE USE OF FENIL-CICLOHEXANO SUBSTITUTES SUBSTITUTED FOR THE MANUFACTURE OF A MEDICINAL PRODUCT FOR THE PROFILACTIC TREATMENT OF A MAMMER IN THE RISK OF DEVELOPING COPD. |
| abstract | The use of substituted phenyl-cyclohexane derivatives for the manufacture of a medicament for the prophylactic treatment of a mammal at risk of developing COPD, which comprises a compound of Formula (I) in which Formula (I) comprises: R1 is - (CR4R5) nC (O) O (CR4R5) mR6, - (CR4R5) nC (O) NR4 (CR4R5) mR6, - (CR4R5) nO (CR4R5) mR6, or - (CR4R5) rR6, in which alkyl moieties they may be optionally substituted with one or more halogens; m is from 0 to 2; nes from 1 to 4; r is from 0 to 6; R4 and R5 are independently selected from hydrogen or a C1-2 alkyl; R6 is hydrogen, methyl, hydroxy, aryl, arylsubstituted with halo, aryloxy-C1-3alkyl, aryloxy-C1-3alkyl substituted with halo, indanyl, indenyl, C7-11 polycycloalkyl, tetrahydrofuranyl, furanyl, tetrahydropyranyl, pyranyl, tetrahydrothienyl, thienyl, tetrahydrothiopyranyl, thiopyranyl, C3-6 cycloalkyl, or a C4-6 cycloalkyl containing one or two unsaturated bonds, wherein the cycloalkyl and heterocyclyl moieties may optionally be substituted with OH, from 1 to 3 methyl groups or an ethyl group; provided that: a) when R6 is hydroxyl, then m is 2; or b) when R6 is hydroxyl, then r is from 2 to 6; or c) when R6 is 2-tetrapyranyl, 2-tetrahydrothiopyranyl, 2-tetrahydrofuranyl or 2-tetrahydrothienyl, then m is 1 or 2; or d) when R6 is 2-tetrahydrpiranyl, 2-tetrahydrothiopyranyl, 2-tetrahydrofuranyl or 2-tetrahydrothienyl, then r is 1 to 6; e) when n is 1 and m is 0, then R6 is different from H en- (CR4R5) nO (CR4R5) mR6; X is YR2, halogen, nitro, NR4R5, or formylamine; Y is O or S (O) m; m is 0, 1 or 2; X2 is O or NR8; X3 is hydrogen or X; X4 Sformula (a) or (b); X5 is H, R9, OR8, CN, C (O) R8, C (O) OR8, C (O) NR8R8 or NR8R8; R2 is independently selected from the group consisting of -CH3 and -CH2CH3 optionally substituted with 1 or more halogens; s is 0 to 4; R3 is hydrogen, halogen, C1-4 alkyl, CH2NHC (O) C (O) NH2, C1-4 alkyl substituted with halo, -CH = CR8, R8, R8, cyclopropyl optionally substituted with R8, CN, OR8, CH2OR8, NR8R10, CH2NR8R10, C (Z) H, C (O) OR8, C (O) NR8R10, or C ::: CR8; Z is O, NR9 |
| priorityDate | 1998-01-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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