| abstract |
Acyl guanidines are described, which are inhibitors of proton / sodium exchange (NHE) of formula (I): wherein n is an integer from 1 to 5; wherein X is N or C-R5 where R5 is H, halo, alkenyl, alkyl, alkoxy, alkyl, aryl or heteroaryl; R1 is H, alkyl, alkenyl, alkoxy, alkenyloxy, alkynyloxy, (alkyl or aryl) 3Si (where each alkyl or aryl group is independent), cycloalkyl, cycloalkenyl, amino, alkylamino, alkenylamino, alkylamino, arylalkylamino, aryl, arylalkyl, arylamino, aryloxy, cycloheteroalkyl, cycloheteroalkylalkyl, heteroaryl, heteroarylamino, heteroaryloxy, arylthio, arylsulfinyl, arylsulfonyl, thio, alkylthio, alkylsulfinyl, alkylsulfonyl, heteroarylthio, heteroarylsulfinyl, heteroarylsulfonyl, halogen, haloalkyl, polyhaloalkyl such as CF3 and CF3CH2, polyhaloalkyloxy such as CF 3 O and CF3CH2O, aminothio, aminosulfinyl, aminosulfonyl, alkylsulfonylamino, alkenylsulfonylamino, alquinilsulfonilamino, arylsulfonylamino, heteroarylsulfonylamino, alkylaminocarbonyl, arylaminocarbonyl, heteroarylaminocarbonyl, hydroxy, acyl, carboxy, aminocarbonyl, alkylcarbonyl, alkoxycarbonyl, alkylcarbonyloxy, alkylcarbonylamino, arylcarbonyl, arylcarbonyloxy, arylcarbonylamino, het eroarilcarbonilo, heteroarylcarbonyloxy, heteroarylcarbonylamino, cyano, nitro, alkenylcarbonylamino, alquinilcarbonilamino, alkylaminocarbonylamino, alkenylaminocarbonylamino, alquinilaminocarbonilamino, arylaminocarbonylamino, heteroarylaminocarbonylamino, alkoxycarbonylamino, alkenyloxycarbonylamino, alkynyloxycarbonylamino, aryloxycarbonylamino, alkylaminocarbonyloxy, 1,1- (alkoxyl or aryloxy) 2 -C (wherein the two substituents of aryl or of |