| abstract |
Spiroazobicyclic heterocyclic amines of formula (I) in which n is 0 or 1; m is O or 1: p is O or 1; X is oxygen or sulfur; Y is CH, N or NO; W is oxygen, H2 or F2; A is N or C (R2), G is N or C (R3), D is N or C (R4), with the proviso that not more than one of A, G and D is nitrogen but at least one of Y, A , G and D are nitrogen or NO; R1 is hydrogen or C1-4alkyl, R2, R3 and R4 are independently hydrogen, halogen, C1-4alkyl, C2-4alkenyl, C2-4alkynyl, aryl, heteroaryl, OH, OC1-4alkyl, CO2R1, -CN , NO2, -NR5R6, -CF3, -OSO2CF3, or R2 and R3 or R3 and R4, respectively, may together form another six-membered aromatic or heteroaromatic ring, A and G, or G and D, respectively, containing between zero and d or s nitrogen atoms and you are substituted with one or two of the following substituents; independently hydrogen, halogen, C1-4alkyl, C2-4alkenyl, C2-4alkynyl, aryloheteroaryl, OH, Oc1-4alkyl, CO2R1, -CN -NO2, -NR5R6, -CF3, -OSO-CF 3; R5 and R6 independently represent hydrogen, C1-4alkyl, C (O) R7, C (O) NHR8, C (O) OR9, SO2R10 or together may consist of (CH2) jQ (CH2) k where Q is O, S , NR11 or a link; j is 2 to 7; k is 0 or 2; R7, R8 R9, R10, R11 are independently C1-4alkyl, aryl or heteroaryl, or an enantiomer thereof, as well as pharmaceutically acceptable salts thereof, processes for preparing it, a composition containing it, and its use in therapy and in the preparation of drugs , and methods of treatment or prophylaxis of psychotic disorders and disorders of intellectual deterioration. |